Treatment and agents for arousals and snoring associated with breathing effort during sleep

A technology of breathing effort and medicine, applied in the direction of respiratory diseases, antibacterial drugs, drug combination, etc., can solve the problems of relatively loud noise, cumbersome cost, disturbing the sleep of sleeping partners, etc.

Inactive Publication Date: 2011-12-14
菲利普科曼斯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, use of these interventions, such as adhesive nasal strips, can be uncomfortable and can cause skin irritation and irritation, while devices for applying continuous positive air pressure to relieve snoring are inconvenient and can be cumbersome and expensive
The air pumps used in such devices can also be relatively noisy thus disturbing the sleep of sleeping partners as well as others within hearing range of the pump

Method used

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  • Treatment and agents for arousals and snoring associated with breathing effort during sleep
  • Treatment and agents for arousals and snoring associated with breathing effort during sleep
  • Treatment and agents for arousals and snoring associated with breathing effort during sleep

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0044] Example 1: The effect of antibiotic ointment on snoring and sleep quality

[0045] A study was conducted to evaluate the effect of mupirocin ointment on snoring and sleep patterns in male subjects with a history of snoring and sleep disturbances. The subject had been identified as having chronic colonization of the nares with Staphylococcus aureus (methicillin-susceptible Staphylococcus aureus) prior to the start of the study.

[0046] Mupirocin ointment (Bactroban TM, GlaxoSmithKline) was applied to the base of each nostril of the subject and just inside his nostril. The subject's sleep partner (wife, age 46) was reluctant to not use earplugs that night. Follow-up observations were recorded over a subsequent 16-day period, and the subject's degree of nasal obstruction and snoring, as well as his and his wife's morning refreshment, were assessed. No mupirocin ointment was administered to the subject during the 16-day observation period.

[0047] 1. Demographic detai...

example 2

[0070] Example 2: Effect of probiotic Lactobacillus acidophilus / Bifidobacterium animalis on snoring and sleep quality

[0071] The subjects described in Example 1 (male) had a history of snoring, sleep disturbance, and daytime fatigue. This contributed to the sleep disturbance of his sleeping partner (wife). Such as figure 1 As depicted in , investigations have shown that subjects' nostrils have been chronically colonized with Staphylococcus aureus (Methicillin-susceptible Staphylococcus aureus). Probiotics (Lactobacillus acidophilus / Bifidobacterium animalis) are known to enhance immune system performance in general by sharing the mucosal immune system. A study was conducted to determine whether oral treatment of a male subject with a probiotic (Lactobacillus acidophilus / Bifidobacterium animalis) could reduce nasal colonization with S. aureus and improve the subject's snoring and sleep patterns.

[0072] Give the subject an initial dose of 2 capsules containing probiotics,...

example 3

[0089] Example 3: Dose response effect of the probiotic Lactobacillus acidophilus / Bifidobacterium animalis on snoring and sleep quality

[0090] In a third study, the dose-response to probiotic treatment of the subjects (male) described in Examples 1 and 2 was evaluated to determine 2×10 9 and 5x10 9 Whether orally treated subjects with doses of probiotics (Lactobacillus acidophilus / Bifidobacterium animalis) for each bacterium reduced nasal colonization by Staphylococcus aureus and improved snoring and sleep patterns in subjects.

[0091] After a washout period of 9 days, the subject was orally administered 5 capsules containing probiotics (white capsules containing Lactobacillus acidophilus / Bifidobacterium animalis, 10 9 Bio / capsules; Blackmore, Warlewood, NSW, Australia) The initial dose was given for 4 days, followed by 2 capsules given for 3 days. The self-assessment parameters recorded by the subject and his wife were scored on a scale of 1 to 7, with 1 being very good ...

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Abstract

Provided herein is a method for preventing or treating respiratory effort-related arousals during sleep in a subject. The method includes administering to the subject an effective amount of an agent to reduce or inhibit infection or colonization of the subject's nasal cavity by S. aureus. Typically, the breathing effort-related arousals are associated with snoring. The agent may be selected from the group consisting of antibiotics, immunostimulants, probiotics, and mixtures of the foregoing. Also provided herein is a method for preventing or treating snoring comprising administering the agent to the subject.

Description

field of invention [0001] The present invention relates to a method for preventing or treating a sleep-related disorder in a subject using an agent for reducing or inhibiting the colonization of the nasal cavity of a subject by Staphylococcus aureus. Background of the invention [0002] Snoring arises from vibrations of the soft tissues of the oropharynx and is a common phenomenon in the general population, with some reports suggesting that at least 20% of people snore. It is most common in middle-aged men, although women after menopause become more prone to snoring. Snoring is also associated with adverse health outcomes, including fatigue and high blood pressure, as well as more serious conditions such as ischemic heart disease and cerebral ischemia. [0003] In-depth snoring studies have shown that it often has more than one cause and multiple risk factors have been identified, including smoking, alcohol, obesity, various physiological causes (eg, septal curvature and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/04A61K39/07A61K39/05A61P31/04A61K35/745A61K35/747
CPCA61K35/747A61K35/745A61K31/00A61P11/00A61P11/02A61P25/20A61P31/04A61P37/04A61K2300/00A61K31/04A61K39/04A61K39/05A61K39/07
Inventor 菲利普.科曼斯
Owner 菲利普科曼斯
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