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Extraction method of schisandra total lignans

A technology of total lignans and extraction method, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of low content, low yield and high energy consumption, and achieves simple extraction process, transfer The effect of high rate and high yield

Inactive Publication Date: 2013-08-07
HARBIN RENHUANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings of previous methods for extracting total lignans from Schisandra chinensis, such as low yield, low content, high energy consumption, long production cycle, and environmental pollution, one of the purposes of the present invention is to provide a high-efficiency extraction method for total lignans from Schisandra chinensis

Method used

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  • Extraction method of schisandra total lignans

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for extracting total lignans from Schisandra chinensis, comprising the steps of:

[0023] (1) Pulverize the schisandra medicinal material into medium powder (the powder is more than 65 mesh, but mixed with no more than 60% of the powder that can pass through the 80 mesh sieve), and set aside; (2) The mass fraction of the pulverized medicinal material powder is 50% Soak in ethanol for 36 hours and then percolate, collect 10 times the amount of medicinal material (ml / g) percolation solution, concentrate the percolation solution under reduced pressure to obtain a concentrated solution, the ratio of the volume of the concentrated solution (ml) to the weight of the used medicinal material (g) is 3:1 , for subsequent use; (3) the concentrated solution is adjusted to increase the ethanol concentration to 80% (w / w) of alcohol content, and the insoluble matter is filtered out, and the filtrate is for subsequent use; (4) the filtrate is passed through 12 times the weight ...

Embodiment 2

[0026] A method for extracting total lignans from Schisandra chinensis, comprising the steps of:

[0027] (1) Crushing the schisandra medicinal material into medium powder (the powder is more than 65 mesh, but not more than 60% of the powder that can pass through the 80 mesh sieve is mixed), and set aside; (2) the mass fraction of the crushed medicinal material powder is 55%. Soak in ethanol for 24 hours and then percolate, collect 10 times the amount of medicinal material (ml / g) percolation solution, concentrate the percolation solution under reduced pressure to obtain a concentrated solution, the ratio of the volume (ml) of the concentrated solution to the weight (g) of the medicinal material used is 2:1 , for subsequent use; (3) the concentrated solution is adjusted to increase the ethanol concentration to 90% (w / w) of alcohol content, and the insoluble matter is filtered out, and the filtrate is for subsequent use; (4) the filtrate is passed through 10 times the weight of t...

Embodiment 3

[0030] A method for extracting total lignans from Schisandra chinensis, comprising the steps of:

[0031] (1) Pulverize the schisandra medicinal material into medium powder (the powder is more than 65 mesh, but mixed with no more than 60% of the powder that can pass through the 80 mesh sieve), and set aside; (2) The mass fraction of the pulverized medicinal material powder is 60%. Soak in ethanol for 12 hours and then percolate, collect 10 times the volume (ml / g) of the medicinal materials, and concentrate the percolation liquid under reduced pressure to obtain a concentrated solution. The ratio of the volume (ml) of the concentrated solution to the weight (g) of the medicinal materials used is 1:1 , for subsequent use; (3) the concentrated solution is adjusted to increase the ethanol concentration to 95% alcohol content (w / w), and the insoluble matter is filtered out, and the filtrate is for subsequent use; Purified by column (activated at 110°C for 6h before alumina use), 0.1%...

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Abstract

The invention discloses an extraction method of schisandra total lignans. The method comprises the following steps: (1) crushing a schisandra medicinal material into medium powder for later use; (2) soaking the crushed medicinal material powder with 40-60 percent ethanol for 12 to 36 hours, percolating, and concentrating the percolate at reduced pressure to obtain concentrated solution for later use, wherein the ratio of the volume of the concentrated solution to the weight of the medicinal material is (1-3):1; (3) regulating the concentration of ethanol in the concentrated solution to 80 to 95 percent, and filtering; (4) purifying the filtrate with an alumina column, receiving column passing solution, decoloring with activated carbon for 0.5 to 2 hours at room temperature, and filtering,wherein the dosage of activated carbon is 0.1 to 0.2 percent; and (5) concentrating the filtrate at reduced pressure, drying in vacuum to obtain yellow or brownish yellow solid schisandra total lignans. The extraction method has the advantages of convenience, low energy consumption and the like, and the yield of extracted total lignans is high; and the purification method has the advantages of strong selectivity, complete impurity removal and the like and the purity of total lignans is high.

Description

technical field [0001] The invention relates to a method for extracting total lignans from Schisandra chinensis, in particular to a method for extracting total lignans from Schisandra chinensis by ethanol percolation, and belongs to the technical field of traditional Chinese medicine extraction. Background technique [0002] Schisandra chinensis (Turcz.) Ball. is the dried and mature fruit of perennial deciduous woody vines of Magnoliaceae. , the effect of invigorating the kidney and calming the heart. Modern studies have proved that in addition to protecting the liver and reducing enzymes, the lignans in Schisandra chinensis also have various functions such as central nervous system inhibition, anti-oxidation, anti-cancer, and blood pressure regulation. Precious Chinese herbal medicines. Currently, the Chinese patent medicines containing Schisandra chinensis sold in the market include single prescriptions and compound prescriptions. Occurrence of adverse reactions. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P35/00A61P25/00A61K36/57A61P1/16A61P9/00A61P39/06A61K31/09
Inventor 于喜水李绍铭王晶刘晓磊张晓燕翟春梅王萍萍
Owner HARBIN RENHUANG PHARMA