Blood-sugar-reducing composition and application thereof

A composition and blood sugar technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of insulin deficiency, insulin effect discount, insulin loss, etc., and achieve the effect of lowering blood sugar level

Inactive Publication Date: 2012-01-04
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The ability to produce insulin in patients with type 2 diabetes is not completely lost, and some patients even produce too much insulin, but the effect of insulin is greatly reduced, so the insulin in the patient's body is in a state of relative deficiency
Its antioxidant function and insuli

Method used

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  • Blood-sugar-reducing composition and application thereof
  • Blood-sugar-reducing composition and application thereof
  • Blood-sugar-reducing composition and application thereof

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Embodiment Construction

[0032] The composition for lowering blood sugar provided by the present invention is a compound combination of insulin and selenium to make an injection, and the antioxidant effect and insulin-like effect of selenium are also the basis for the rationality of combined use of insulin and selenium. The compound combination can lower the blood sugar level in diabetes, and the hypoglycemic effects of insulin and sodium selenite are mutually enhanced, and the 2-hour hypoglycemic effect of the compound insulin selenium injection is stronger than that of the same dose of insulin alone. The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0033] 1. Combination ratio of insulin and selenium composition and its hypoglycemic effect

[0034] 1) Establishment of experimental type 2 diabetes rat model

[0035] An experimental type 2 diabetic rat model was establish...

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Abstract

The invention discloses a blood-sugar-reducing composition and application thereof. In the blood-sugar-reducing composition, insulin and selenium are combined according to an insulin-selenium ratio of 1U:(1-40mu g).In the blood-sugar-reducing composition, the insulin and selenium are subjected to compound combination, and the antioxidation action and the insulin-like action of the selenium further provide a foundation for the reasonable compound combination of the insulin and selenium. The compound composition can reduce the blood sugar level of a diabetic, and the blood sugar concentration can be reduced to about 80% two hours after the composition is taken, wherein the insulin has more obvious blood-sugar-reducing action, thereby being the main drug; and sodium selenite has less action in comparison with the insulin, thereby being the adjuvant drug. The combination of the selenium and the insulin can reduce the dose of the insulin, and the combination has a better curative effect in comparison with the single use of the insulin.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of diabetes, and relates to a composition for lowering blood sugar and an application thereof. Background technique [0002] 1. Overview of diabetes [0003] Diabetes mellitus (DM) is a metabolic disease characterized by elevated blood sugar due to absolute or relative insufficiency of insulin secretion, including type 1 diabetes and type 2 diabetes. Type 2 diabetes (T2DM) accounts for more than 90% of the total number of diabetes, and type 2 diabetes and its complications are spreading globally. According to WHO estimates, by 2025, the number of diabetic patients in the world will reach 300 million, twice the incidence rate in 1995, suggesting that diabetes will become a serious burden on medical resources in the near future. [0004] The ability to produce insulin in patients with type 2 diabetes is not completely lost, and some patients even produce too much insulin, but the ...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61P3/10A61K33/04
Inventor 陈莉娜袁秉祥曾爱国吕娟马欣王嫦鹤王冰
Owner XI AN JIAOTONG UNIV
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