Injectable biomaterials

一种注射组合物、物质的技术，应用在原弹性蛋白领域，能够解决团不能递送、没有具有高固含量等问题
CN102348464AActive Publication Date: 2012-02-08APTALIS PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
APTALIS PHARMA
Publication Date
2012-02-08

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Abstract

Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysaccharide derivative, in an amount effective for providing the substance with the properties of flow, enabling injection.
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Description

technical field

[0001] The present invention relates to tropoelastin and to the use of biomaterials for tissue repair and restoration. Background technique

[0002] Elastin is an extracellular matrix protein found primarily in the skin, blood vessels, lungs, and other tissues and organs that require a certain degree of elasticity to function. It usually forms by cross-linking lysine residues on tropoelastin molecules with lysine residues on other tropoelastin molecules, forming clusters that are nearly insoluble in aqueous solutions.

[0003] Elastin, tropoelastin, and related proteins are expected to be useful in medical applications including tissue repair and restoration, and there is a particular need for compositions of such proteins with high solids content that can be administered to tissue by injection. Although microparticles formed from biological materials are mentioned in WO99 / 11196 and WO2008 / 058323, there are no compositions of smaller particle structures with...

Claims

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