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Compositions comprising injectable biomaterial cement and radiopacity-improving agent

A radiopaque, biomaterial technology applied in the field of strontium bromide and/or strontium iodide, which can solve the problems of reduced mechanical properties, low solubility, etc. of the hardened end product

Inactive Publication Date: 2014-07-23
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] US4,797,431, US5,106,301, US2003 / 0199605Al describe the use of strontium fluoride (SrF 2 ) and strontium chloride as radiopacity agents, mainly used in dental applications; however, SrF 2 Has very low solubility and significantly reduces the mechanical properties of the hardened final product

Method used

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  • Compositions comprising injectable biomaterial cement and radiopacity-improving agent
  • Compositions comprising injectable biomaterial cement and radiopacity-improving agent
  • Compositions comprising injectable biomaterial cement and radiopacity-improving agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Brushite cement having the composition as in Table 1 was prepared by first dissolving monocalcium phosphate monohydrate (MCPM) and disodium dihydrogen pyrophosphate (1 wt %) in distilled water. Upon dissolution, a mixture of β-tricalcium phosphate (β-TCP) and strontium bromide (2, 10, and 20 wt%, respectively) was introduced. The total powder to liquid ratio was 3.3 g / mL and the molar ratio of MCPM:β-TCP was 1:1.

[0060] Table 1: Containing SrBr 2 Radiopaque brushite preparations

[0061]

Embodiment 2

[0063] Brushite cement having the composition as in Table 2 was prepared by first dissolving monocalcium phosphate monohydrate (MCPM) and disodium dihydrogen pyrophosphate (1 wt %) in distilled water. Upon dissolution, a mixture of β-tricalcium phosphate (β-TCP) and strontium iodide (2, 5, 10, 15, and 20 wt%, respectively) was introduced. The total powder to liquid ratio was 3.3 g / mL and the molar ratio of MCPM:β-TCP was 1:1.

[0064] Table 2: Containing SrI 2 Radiopaque brushite preparations

[0065]

[0066] The preparation and testing methods are the same for Examples 1 and 2, which will be explained next. When the liquid and powder components were mixed for 30 seconds, samples were molded for radiopacity studies, compression tests, and in vitro direct contact viability assays.

[0067] radiopacity

[0068] For radiopacity testing, discs of 1 mm height and 10 mm diameter were molded. at 72kV p Samples were down-illuminated and radiopacity was calculated relative ...

Embodiment 3

[0082] In this example, cements prepared from compositions according to the invention were compared with various comparative and commercial products containing conventional additives. All reagents were purchased from Sigma-Aldrich (Sigma-Aldrich, St. Louis, MO, USA), unless otherwise specified. The composition according to the invention was prepared with a powder to liquid ratio of 3.3 g / ml and a molar ratio of MCPM:P-TCP of 1:1. First, appropriate amounts of MCPM (purum p.a., ≥85, KT) and disodium dihydrogen pyrophosphate (1 wt% of the total amount of powder) were mixed with distilled water to form a slurry. Second, an appropriate amount of β-TCP (purum p.a., ≥96, calculated as Ca 3 (PO 4 ) 2 , KT) and SrX (10 wt% of the total mass), were added to the slurry and mixed with a metal spatula for 30 seconds. The following SrXs were tested: strontium fluoride, strontium chloride hexahydrate (SrCl 2 ? 6H2 O), strontium bromide, and strontium iodide. For simplicity, the mater...

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Abstract

Compositions suitable for use as, for example, dental, craniofacial or long-bone fillers, percutaneous vertebroplasty agents and kyphoplasty agents, comprise an injectable biomaterial cement and a radiopacity-improving agent in an amount sufficient to improve the radiopacity of the injectable biomaterial in vivo. The radiopacity agent comprises strontium bromide (SrBr2) and / or strontium iodide (Srl2).

Description

technical field [0001] The present invention relates to cement compositions having good radiopacity combined with other properties which are beneficial for in vivo use, such as in vivo biocompatibility, osteoconductivity, and / or resorbability. In particular, the present invention relates to such compositions, wherein said radiopaque agent comprises a salt of strontium and a halogen, in particular strontium bromide and / or strontium iodide. Background technique [0002] Injectable biomaterials are used, for example, in orthopedics, tissue engineering, and drug delivery, or as scaffolds for bone repair. Common injectable biomaterials include, but are not limited to, acrylic bone cements and calcium-based cements, such as calcium phosphate cement (CPC), calcium sulfate cement, and calcium silicate cement. Radiopacity agents are often included in injectable biomaterial formulations in order to improve radiopacity for radiography, computed tomography, and / or real-time fluoroscopy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/50A61L24/02A61K49/00
CPCA61L27/025A61K49/0409A61L24/001A61L24/02A61L27/50A61L2400/06A61L2430/02
Inventor 亚历杭德罗·洛佩斯霍坎·恩奎斯特
Owner OSSDSIGN
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