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Application of resveratrol in preparation of medicines for treating P2X3-mediated chronic pain diseases

A technology of resveratrol and medicine is applied in the application field of resveratrol in the preparation of medicines for treating P2X3-mediated chronic pain diseases, and can solve the problem of no resveratrol analgesic effect, anti-nociceptive reaction affecting pain sensation And other issues

Inactive Publication Date: 2012-03-28
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Resveratrol has anti-inflammatory effects, and may have the effect of anti-nociceptive response and affecting pain perception, but there is no report that resveratrol directly has analgesic effect, and there is no clinical mechanism of resveratrol through analgesic effect reports of pain management

Method used

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  • Application of resveratrol in preparation of medicines for treating P2X3-mediated chronic pain diseases
  • Application of resveratrol in preparation of medicines for treating P2X3-mediated chronic pain diseases
  • Application of resveratrol in preparation of medicines for treating P2X3-mediated chronic pain diseases

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Experimental program
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Effect test

Embodiment 1

[0062] Oral, injection or topical (such as local application) resveratrol preparations suitable for chronic pain treatment are prepared by methods known in the art. Compared with the experimental results of rats in the non-steroidal anti-inflammatory analgesic drug indomethacin treatment group, it shows that resveratrol acts on P2X 3 Receptors produce analgesic effects. Compared with the side effects of opioids and other analgesics, it is easy to produce drug tolerance and dependence and withdrawal syndrome, and the anti-inflammatory analgesics such as indomethacin have large side effects. Resveratrol has less side effects and is more conducive to Its development and application as an analgesic drug.

Embodiment 2

[0064] Using methods well known in the art, made suitable for P2X 3 Receptor Antagonists for P2X 3 Resveratrol preparations for scientific research on receptor signaling. Applied research through the formulation as resveratrol may become a P2X 3 Drugs for receptor-mediated disease prevention and treatment provide the preliminary basis.

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Abstract

The invention relates to a new purpose of resveratrol in the pharmaceutical field, that is, an application of resveratrol in the preparation of medicines for treating P2X3-mediated chronic pain diseases. Experimental observation results show that resveratrol can inhibit pain related behaviors, and observation results of experiments applied with technologies of immunohistochemistry, in situ hybridization, RT-PCR, protein blotting and the like show that resveratrol can inhibit the mRNA expression and the protein expression of a P2X3 acceptor of the dorsal root ganglia from a neuropathic pain model rat. Experiments confirm that the mechanism of the inhibition effect of resveratrol to chronic pains is the antagonism of the primary sensory ganglion P2X3 acceptor-mediated pain information transmission. According to the invention, a new chronic pain (neuropathic pain) control method is ascertained, and simultaneously a case that resveratrol has effects of P2X3 acceptor antagonists is disclosed, so above observations of the invention are in favor of the application of resveratrol in the preparation of purine X3 acceptor (P2X3 acceptor) specificity antagonists.

Description

technical field [0001] The present invention relates to the invention field of analgesic medicine application, especially relates to resveratrol that can be used to prevent and treat pain in the preparation and treatment of P2X 3 Drugs that mediate chronic pain disorders such as neuropathic pain. Background technique [0002] Pain is a common symptom of most diseases, and it is an unpleasant feeling common to all human beings with great individual differences. Because pain causes great suffering to people, according to the second issue of 2001 "International Pain Society Newsletter" report: the 106th Congress of the United States passed a resolution, announcing that the ten years from January 1, 2001 will be "pain control and Decade of Pain Control and Research. This shows that countries attach importance to pain research. According to the pain time course, pain can be divided into acute pain (physiological pain) and chronic pain (pathological pain). Due to the complex m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P25/00
Inventor 梁尚栋李桂林谢金燕刘双梅涂桂花彭海英
Owner NANCHANG UNIV
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