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Veterinary use soluble powder accessory and preparation method thereof

A technology of soluble powder and excipients, which is applied in the direction of powder transportation, sulfur/selenium/tellurium active ingredients, etc., can solve the problems of decreased solubility of excipients, rising prices of excipients, slow dissolution of drugs in water, etc., to promote reactions, weaken defects, and dissolve quickly Effect

Inactive Publication Date: 2013-06-12
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many excipients commonly used in veterinary soluble powders, and there is a lot of room for veterinary drug companies to choose. However, most veterinary drug companies are still troubled by many excipients, such as easy caking during drug storage; especially in the cold winter in the north, resulting in solubility of excipients decrease, the drug dissolves slowly in water; the price of excipients is rising steadily, resulting in the gradual reduction of profits of veterinary drug companies, etc. Therefore, it is still very important to find or configure a cheap, stable, fast-dissolving, and superior-performance excipient in the veterinary drug market. needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: 500 g yuanming powder, 80 g sodium bicarbonate, 50 g citric acid, 270 g soluble starch, 1 g aspartame, 1 g essence, 50 g polyethylene glycol 6000; 40-mesh sieve, then added to molten polyethylene glycol 6000, stirred until completely dissolved, then cooled rapidly, crushed through 40-mesh, then added the remaining components, and mixed evenly.

Embodiment 2

[0015] Embodiment 2: 400 g Yuanmingfen, 50 g sodium bicarbonate, 30 g citric acid, 100 g soluble starch, 0.5 g aspartame, 0.5 g essence, 60 g polyethylene glycol 6000; wherein citric acid needs to pass 50 Mesh sieve, then add into melted polyethylene glycol 6000, stir until completely dissolved, then cool rapidly, crush to pass 50 mesh, then add remaining components, mix evenly.

Embodiment 3

[0016] Example 3: 600 g yuanming powder, 100 g sodium bicarbonate, 70 g citric acid, 300 g oral glucose, 7 g stevioside, 3 g essence, 210 g polyethylene glycol 6000; wherein citric acid needs to pass through a 60-mesh sieve , and then added to molten polyethylene glycol 6000, stirred until completely dissolved, then cooled rapidly, crushed to 60 mesh, then added the remaining components, and mixed evenly.

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PUM

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Abstract

The invention belongs to the technical field of drug preparations and discloses a veterinary use soluble powder accessory and a preparation method thereof. The veterinary use soluble powder accessory is made of the following components in parts by weight: 50-100 parts of alkali foaming agent, 30-70 parts of acidic foaming agent, 500-900 parts of filling agent, 1-10 parts of flavoring agent and 6000 parts of polyethylene glycol, and the 6000 parts by weight of polyethylene glycol is 1-3 times more than the alkali foaming agent or acidic foaming agent. The alkali foaming agent or acidic foamingagent and the 6000 parts of polyethylene glycol are heated and melted, then cooled, crushed, screened with a sieve of 40-60 meshes, and finally uniformly mixed with surplus components. After the components of the accessory disclosed by the invention are combined for use, the defects of each component in use can be greatly reduced, the price is low, and the prepared accessory has high stability and is dissolved rapidly.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an auxiliary material of veterinary soluble powder and a preparation method thereof. Background technique [0002] Pharmaceutical excipients refer to all medicinal materials added to the prescription except the main drug in order to solve the formability, effectiveness, stability and safety of the preparation during the formulation of the preparation. The essence of the pharmaceutical preparation formulation design process is the process of screening and applying pharmaceutical excipients based on the characteristics of the drug and the requirements of the dosage form. [0003] Pharmaceutical excipients are the basic materials and important components of pharmaceutical preparations, the material basis to ensure the production and development of pharmaceutical preparations, and play a key role in the formulation and production of pharmaceutical preparations. It ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K47/36A61K9/14A61K33/04
Inventor 贺培益柴保国高义
Owner HENAN SOAR VETERINARY PHARMA