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Periplaneta Americana L. and gel externally applied medicinal composition and preparation method and use thereof in preparation of externally applied medicines for treating scalding

A cockroach gel, the technology of American cockroach, which can be applied in the directions of drug combination, drug delivery, medical formulation, etc., can solve the problems of unsatisfactory cure rate and other problems

Active Publication Date: 2012-04-18
ZHEJIANG JINGXIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the weak point when these medicines of prior art are scalded is that the cure rate is not ideal enough

Method used

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  • Periplaneta Americana L. and gel externally applied medicinal composition and preparation method and use thereof in preparation of externally applied medicines for treating scalding
  • Periplaneta Americana L. and gel externally applied medicinal composition and preparation method and use thereof in preparation of externally applied medicines for treating scalding
  • Periplaneta Americana L. and gel externally applied medicinal composition and preparation method and use thereof in preparation of externally applied medicines for treating scalding

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Embodiment 1, Periplaneta americana gel composition for external use, the weight ratio of the ethanol extract of the dried worm body of Periplaneta americana and the gel matrix in the composition is 0.5:100.

[0093] Wherein, the ethanol extract of the dried worm body of Periplaneta americana refers to the extract prepared by the following method:

[0094] ⑴. Dried worms of Periplaneta americana are crushed into coarse powder or not crushed;

[0095] ⑵. Extract several times with 70%~95% ethanol to the American cockroach coarse powder that step ⑴ obtains;

[0096] (3) Combine the extracts, recover ethanol, add purified water to degrease, and concentrate the degreasing solution to a thick paste with a relative density of 1.35;

[0097] ⑷. Preparation of water-soluble gel matrix;

[0098] ⑸. Add the extract thick paste obtained in step ⑶ evenly into the water-soluble gel matrix in proportion.

Embodiment 2

[0099] Embodiment 2 is basically the same as Example 1, but the weight ratio of the ethanol extract of the dry worm body of Periplaneta americana to the gel matrix in the composition is 0.1:100.

Embodiment 3

[0100] Embodiment 3 is basically the same as Example 1, but the weight ratio of the ethanol extract of the dry worm body of Periplaneta americana to the gel matrix in the composition is 2.5:100.

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Abstract

The invention discloses periplaneta Americana L. and gel externally applied medicinal composition and a preparation method and use thereof in preparation of externally applied medicines for treating scalding. The periplaneta Americana L. gel externally applied medicinal composition is prepared from ethanol extract of dried periplaneta Americana L. and a water soluble gel substrate according to weight ratio of the ethanol extract of dried periplaneta Americana L. to the water soluble gel substrate of (0.1-2.5):100, preferably 0.5:100. The preparation method comprises: grinding dried periplaneta Americana L. into coarse powder or preparing non-ground dried periplaneta Americana L.; extracting the periplaneta Americana L. in 70-to-95-percent ethanol for several times; combining extract, recovering ethanol, adding purified water for defatting, concentrating the defatted solution till thick paste with a relative density of 1.35; preparing water soluble gel substrate; and uniformly adding the thick paste of the extract into the water soluble gel substrate according to a ratio. When the periplaneta Americana L. and gel externally applied medicinal composition is used as an externally applied medicine, the dosage of the periplaneta Americana L. is 2.0g / kg.d, and two doses are taken. The periplaneta Americana L. and gel externally applied medicinal composition can treat scalding effectively, and is a good preparation with a development value.

Description

technical field [0001] The present invention relates to a Periplaneta americana gel composition for external use, a method for preparing the Periplaneta americana gel composition for external use, and the use of the Periplaneta americana gel composition for external use in preparing external medicine for treating scalds application. Background technique [0002] Burns (hereinafter referred to as "scalds") refer to the direct action of burning objects and hot liquids, solids, gases, and electric currents on the human body, causing skin scalds or burns, and even fire poison internally attacking viscera, often accompanied by flushing and edema, and a large amount of exudation on the surface. It is an injury disease mainly manifested by redness, swelling, burning pain, blistering, and eschar formation of the wound. In mild cases, it will damage the skin and fur, and in severe cases, it will damage the muscles and tendons. In severe cases, the fire and poison will be blazing. I...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/00A61P17/02
Inventor 王光强马鹏程张利峰徐小军沈永年
Owner ZHEJIANG JINGXIN PHARMA
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