PH-sensitive organic and inorganic composite medicament delivery system and preparation method thereof
A delivery system and composite technology, applied in the field of organic-inorganic composite drug delivery systems, can solve problems such as poor mechanical properties of hydrogels, weak adsorption force, application limitations, etc., to increase reaction sites, improve utilization, reduce Effects of Drug Loss and Side Effects
Inactive Publication Date: 2013-04-17
ZHEJIANG SCI-TECH UNIV
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However, hydrogels have poor mechanical properties, are unstable in physiological environments, have less adsorption capacity for drugs, and often have weak adsorption forces, so their applications are limited.
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[0018] Based on the phenomenon of hydrogel phase separation, the invention designs the synthesis of calcium carbonate-hydrogel composite nanomaterials. Under the action of high ion concentration, the hydrogel undergoes phase separation to form spherical vesicles, which contain reactive ions, and use electric current to promote the movement of ions. Due to the interaction between calcium ions and amide groups, calcium carbonate pores are formed inside the hydrogel. microspheres to obtain calcium carbonate-hydrogel composite nanomaterials. β-cyclodextrin is added into the hydrogel, and its inclusion effect is used to increase the drug loading of hydrophobic drugs and control their release.
[0019] The pH-sensitive organic-inorganic composite drug delivery system of the invention is mainly composed of polyacrylamide hydrogel and porous calcium carbonate, and the volume ratio of polyacrylamide hydrogel and porous calcium carbonate is 1:1. Among them, polyacrylamide hydrogel is c...
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Abstract
The invention discloses a pH-sensitive polymer-inorganic matter composite medicament release system which mainly comprises polyacrylamide hydrogel and porous calcium carbonate, wherein the polyacrylamide hydrogel is prepared from acrylamide, N'N-methylene-bisacrylamide, sodium metabisulfite, ammonium persulfate, beta-cyclodextrin, deionized water and tris(hydroxymethyl) aminomethane hydrochloride. By using a current assistance method, calcium ions and carbonate react inside a hydrogel network structure to generate calcium carbonate precipitate, so that the calcium carbonate-polyacrylamide hydrogel composite material is prepared. The medicament delivery system has excellent biocompatibility, can specially release medicaments by virtue of pH response and the swelling property of the hydrogel, and has potential clinical application value and commercial value.
Description
technical field [0001] The invention relates to a drug delivery system, in particular to a pH-sensitive organic-inorganic composite drug delivery system suitable for targeted delivery of clinical drugs. Background technique [0002] Traditional drug delivery systems such as solutions, suspensions, and emulsions have disadvantages such as large drug dosage, low efficacy, first-pass effect, incompatibility, instability, fluctuation of drug levels in plasma, and poor lasting effect, making their application limited. Therefore, the preparation of drug delivery systems that can meet special requirements has become an urgent need. Current research hotspots focus on the use of porous inorganic nanomaterials combined with targeting systems to prepare much-needed targeted drug delivery systems. In the past few decades, drug delivery systems prepared from nanomaterials have generated tremendous growth in the industrial field. Commercial profits, generating on average more than $200 m...
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IPC IPC(8): A61K47/32C08F220/56C08J3/075A61K47/02
Inventor 董文钧刘法家罗亮王丁振
Owner ZHEJIANG SCI-TECH UNIV