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Method for extracting actinodaphnine from actinodaphne obovata

A technology of carnitine and carnitine, which is applied in the preparation field of extracting carnitine from plants, to achieve the effects of less pollution, favorable large-scale production operations, and low energy consumption

Inactive Publication Date: 2012-05-02
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In the prior art, there is no report on the preparation process applicable to the industrialized large-scale production of high-purity carnitine

Method used

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  • Method for extracting actinodaphnine from actinodaphne obovata

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Effect test

Embodiment 1

[0024] Get 10Kg of the bark of Phoebe Phoebe Phoebe, crush it, and add it to CO 2 In the supercritical extractor, ethyl acetate is used as the entrainer, the entrainer accounts for 1% by volume of the total extraction solvent, the extraction pressure is 10MPa, the temperature is 40°C, CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 120min, and the extract is obtained, dissolved in ethanol, filtered, and the filtrate is taken, adsorbed by a 001×7 strong acidic styrene-type cation exchange resin column, and hydrochloric acid with a concentration of 1mol / L Solution elution, collect the eluent, pass through a 201×7 strong basic styrene-type anion exchange resin column, collect the effluent, concentrate, add to the D102 macroporous adsorption resin column, elute with 40% ethanol, collect 3 Double the column volume eluate, recover ethanol under reduced pressure and concentrate, add absolute ethanol to crystallize, separate and crystallize, wash and dry to obtain 0...

Embodiment 2

[0026] Get 10Kg of the bark of Phoebe Phoebe Phoebe, crush it, and add it to CO 2 In the supercritical extractor, ethyl acetate is used as the entrainer, the entrainer accounts for 3% by volume of the total extraction solvent, the extraction pressure is 30MPa, the temperature is 50°C, CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 140min, and the extract is obtained, dissolved in ethanol, filtered, and the filtrate is taken, adsorbed by a 001×4 strong acidic styrene-type cation exchange resin column, and hydrochloric acid with a concentration of 1mol / L Solution elution, collect eluate, pass through 201×4 type strong basic styrene type anion exchange resin column, collect effluent, concentrate, add to D102 macroporous adsorption resin column, elute with 40% ethanol, collect 8 times the column volume eluate, recover ethanol under reduced pressure and concentrate, add absolute ethanol to crystallize, separate and crystallize, wash and dry to obtain 0.67g of ca...

Embodiment 3

[0028] Get 10Kg of the bark of Phoebe Phoebe Phoebe, crush it, and add it to CO 2 In the supercritical extractor, ethyl acetate is used as an entrainer, the entrainer accounts for 2% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 45°C, CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 130min, and the extract is obtained, dissolved in ethanol, filtered, and the filtrate is taken, adsorbed by a D001 strong acidic styrene-type cation exchange resin column, and washed with a hydrochloric acid solution with a concentration of 1mol / L. Remove, collect the eluate, pass through the D201 type strong basic styrene type anion exchange resin column, collect the effluent, concentrate, add to the D102 type macroporous adsorption resin column, elute with 40% ethanol, collect 5 times the volume of the column The eluate was recovered from ethanol under reduced pressure and concentrated, added absolute ethanol to crystallize, sepa...

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Abstract

The invention relates to a method for extracting actinodaphnine from actinodaphne obovata. The method is easy and convenient to operate, light in pollution and less in energy consumption. The method comprises the following steps of: crushing actinodaphne obovata barks, adding into a CO2 supercritical extractor, and extracting by taking ethyl acetate as an entrainer to obtain an extract; dissolving in ethanol, filtering to obtain filtrate; adsorbing the filter by using a strongly-acidic styrene cation exchange resin column, eluting by using 1 mol / L of a hydrochloric acid solution, and collecting eluent; collecting effluent by using a strong basic anion-exchange resin column, concentrating, and adding to a D102 macroporous adsorption resin column; and eluting by using 40 percent ethanol, adding absolute ethanol for crystallizing, separating crystals, washing, and drying to obtain the actinodaphnine. The actinodaphnine prepared by the method has high purity, and the amplification of industrialization is easy to realize.

Description

technical field [0001] The invention relates to a preparation method of carnitine, in particular to a preparation method of extracting carnitine from plants. Background technique [0002] Actinodaphnine, molecular formula: C 18 h 17 NO 4 , molecular weight: 311.337, CAS accession number: 517-69-1, exists in a variety of plants in the Lauraceae family, among which the lauraceae plant is obovate-leafed and yellow-leaved. Actinodaphne obovata (Nees ) Blume is abundant in the bark of the tree. Its molecular formula is as follows. [0003] [0004] Modern studies have shown that carnitine has strong antibacterial and anti-inflammatory effects, and it is also used as a raw material for the synthesis of other active derivatives. [0005] Rosaceae Plant Phoebe Agrimonia pilosa The bark of Ledeb. is used as a traditional Chinese medicine Aesculus aesculus. Can dispel wind and activate blood circulation, dredge channels and collaterals, continue muscles and bones. [000...

Claims

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Application Information

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IPC IPC(8): C07D491/06
CPCY02P20/54
Inventor 王峰王琳张发成
Owner SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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