Preparation method of cinnamic aldehyde

A technology of cinnamaldehyde and cinnamon bark is applied in the field of preparation of cinnamaldehyde, and can solve the problems of serious pollution, unfavorable large-scale production operations, low cinnamaldehyde content and the like

Inactive Publication Date: 2010-05-12
南京璇荣贸易有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In the prior art, the extraction and separation of cinnamon aldehyde mainly adopts the organic solvent method, etc., but the content of cinnamic aldehyde obtained by these extraction processes is low, the pollution is serious in the production process, and it is unfavorable for large-scale production operations

Method used

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  • Preparation method of cinnamic aldehyde

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Experimental program
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Effect test

Embodiment 1

[0018] Get 10Kg of cinnamon bark fine powder, add to CO 2 In the supercritical extractor, dichloromethane is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 2%, the extraction pressure is 10MPa, the temperature is 30°C, and the CO 2 The flow rate was 1ml / g crude drug / min, the extraction time was 80min, and the extract was obtained, which was dehydrated by adding anhydrous sodium sulfate, filtered, recovered methylene chloride and dried to obtain 8.3g of cinnamaldehyde, which was detected by HPLC with a purity of 98.9%.

Embodiment 2

[0020] Get 10Kg of cinnamon bark fine powder, add to CO 2 In the supercritical extractor, dichloromethane is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 40MPa, the temperature is 60°C, and the CO 2 The flow rate was 5ml / g crude drug / min, the extraction time was 200min, and the extract was obtained, which was dehydrated by adding anhydrous sodium sulfate, filtered, and the dichloromethane was recovered and dried to obtain 11.3g of cinnamaldehyde, which was detected by HPLC with a purity of 98.3%.

Embodiment 3

[0022] Get 10Kg of cinnamon bark fine powder, add to CO 2 In the supercritical extractor, dichloromethane is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 20MPa, the temperature is 50°C, and the CO 2 The flow rate was 2ml / g crude drug / min, the extraction time was 100min, and the extract was obtained, which was dehydrated by adding anhydrous sodium sulfate, filtered, and the dichloromethane was recovered and dried to obtain 13.0g of cinnamic aldehyde, which was detected by HPLC with a purity of 99.4%.

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Abstract

The invention relates to a preparation method of cinnamic aldehyde, with simple and convenient operation, small pollution and less equipment investment. The preparation method comprises the following technical steps: taking and adding cinnamon bark fine powder in a CO2 supercritical fluid extractor, taking dichloromethane as entrainer which accounts for 2-6% of the total volume of extraction solvent, conducting extraction for 80-200min, at extraction pressure of 10-40MPa, temperature of 30-60DEG C, and CO2 flow rate of 1-5ml / g crude drug / min, obtaining extract, adding sodium sulphate anhydrous for dehydration, filtering, recovering the dichloromethane, and then conducting drying, thus obtaining the cinnamic aldehyde. The cinnamic aldehyde prepared by the method has high product purity and is easy to realize industrialization amplification.

Description

technical field [0001] The invention relates to a preparation method of cinnamon aldehyde, in particular to a method for extracting cinnamon aldehyde from plants. Background technique [0002] Cinnamaldehyde (Cinnamaldehyde), synonym: Cinnamal, Cinnamic aldehyde, etc. Molecular formula: C 9 h 8 O, molecular weight: 132.162, CAS accession number: the structural formula is as follows: [0003] [0004] Cinnamic aldehyde is a natural compound with antipyretic and sedative effects, and widely exists in a variety of plants. [0005] The traditional Chinese medicine cinnamon is the dry bark of Cinnamomum cassia Presl, a plant in the Lauraceae family. It has the functions of nourishing fire and yang, igniting fire to its source, dispelling cold and relieving pain, promoting blood circulation and stimulating menstruation, etc. It is rich in cinnamaldehyde. [0006] In the prior art, the extraction and separation method of cinnamon aldehyde mainly adopts organic solvent method...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C47/232C07C45/80
CPCY02P20/54
Inventor 张发成毛志英范淦彬
Owner 南京璇荣贸易有限公司
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