Shenkang injection compound preparation for treating chronic renal failure and preparation method of Shenkang injection compound preparation
A technology of compound preparations and raw materials, which is applied in medical formulations and drug delivery, can solve the problems of high usage of Astragalus membranaceus and affect the efficacy of drugs, and achieve high bioavailability, rapid action, and good curative effect
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Embodiment 1
[0086] Example 1 Shenkang injection compound preparation is prepared from the following raw materials: rhubarb 1500g, salvia miltiorrhiza 1500g, astragalus membranaceus 4500g, safflower 1500g.
[0087] During the preparation, after extracting the raw materials rhubarb and salvia miltiorrhiza according to the ratio of the above formula, first alcohol precipitation, detanning, second alcohol precipitation, water precipitation, third alcohol precipitation, and second water precipitation, depyrogenation and sterilization ; then extract astragalus and safflower according to the proportion of the above formula, alcohol precipitation, water precipitation, alcohol precipitation and water precipitation for the second time, depyrogenation and sterilization; finally combine the above two groups of medicinal solutions, dilute, and Ultrafiltration, fine filtration, sterilization.
Embodiment 2
[0088] Embodiment 2 Shenkang injection compound preparation preparation method is: get rhubarb 1500g, salvia miltiorrhiza 1500g, the amount of water added for the first time is 7-12 times the amount of the original medicinal materials, after soaking for 30min, boil for 30min, filter, and the amount of water added for the second time is 7-12 times the amount of the original medicinal material, boil for 30 minutes, filter, add water for the third time to 7-12 times the original medicinal material, boil for 30 minutes, filter, combine three water extracts, concentrate until the relative density is at 60 °C 1.18~1.25, add 95% ethanol until the alcohol content of the liquid is 70%, let stand for 38-60h, take the supernatant and filter until clear, recover the ethanol until the relative density is 1.18~1.25 at 60°C, add 5% gelatin Solution, detanning, add 95% ethanol until the alcohol content is 75%, let it stand for 38-60h, take the supernatant and filter it to clarify, recover the ...
Embodiment 3
[0089] Example 3 Shenkang injection compound preparation preparation method is: take rhubarb 1500g, salvia miltiorrhiza 1500g, the amount of water added for the first time is 10 times the amount of the original medicinal materials, after soaking for 30min, boil for 30min, filter, and the amount of water added for the second time is the amount of the original medicinal materials 8 times the amount of the original medicinal material, boiled for 30 minutes, filtered, the third time added water was 7 times the amount of the original medicinal material, boiled for 30 minutes, filtered, combined three water extracts, concentrated to a relative density of 1.20 to 1.22 at 60 ° C, added 95 % ethanol, until the alcohol content of the medicinal solution is 70%, let it stand for 48-60h, take the supernatant and filter until it is clear, recover the ethanol until the relative density is 1.20-1.22 at 60°C, add 5% gelatin solution, remove tanning, add 95% ethanol, until the alcohol content is...
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