Shenkang injection compound preparation for treating chronic renal failure and preparation method of Shenkang injection compound preparation

A technology of compound preparations and raw materials, which is applied in medical formulations and drug delivery, can solve the problems of high usage of Astragalus membranaceus and affect the efficacy of drugs, and achieve high bioavailability, rapid action, and good curative effect

Active Publication Date: 2014-03-19
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the case of the prescription is also disclosed in the patent document embodiment, the usage amount of Astragalus is high, and astragalus and rhubarb have precipitation reaction, astragalus and salvia miltiorrhiza can also react, if the input amount of astragalus is small in the compatibility of the preparation, it will affect drug effect

Method used

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  • Shenkang injection compound preparation for treating chronic renal failure and preparation method of Shenkang injection compound preparation
  • Shenkang injection compound preparation for treating chronic renal failure and preparation method of Shenkang injection compound preparation
  • Shenkang injection compound preparation for treating chronic renal failure and preparation method of Shenkang injection compound preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0086] Example 1 Shenkang injection compound preparation is prepared from the following raw materials: rhubarb 1500g, salvia miltiorrhiza 1500g, astragalus membranaceus 4500g, safflower 1500g.

[0087] During the preparation, after extracting the raw materials rhubarb and salvia miltiorrhiza according to the ratio of the above formula, first alcohol precipitation, detanning, second alcohol precipitation, water precipitation, third alcohol precipitation, and second water precipitation, depyrogenation and sterilization ; then extract astragalus and safflower according to the proportion of the above formula, alcohol precipitation, water precipitation, alcohol precipitation and water precipitation for the second time, depyrogenation and sterilization; finally combine the above two groups of medicinal solutions, dilute, and Ultrafiltration, fine filtration, sterilization.

Embodiment 2

[0088] Embodiment 2 Shenkang injection compound preparation preparation method is: get rhubarb 1500g, salvia miltiorrhiza 1500g, the amount of water added for the first time is 7-12 times the amount of the original medicinal materials, after soaking for 30min, boil for 30min, filter, and the amount of water added for the second time is 7-12 times the amount of the original medicinal material, boil for 30 minutes, filter, add water for the third time to 7-12 times the original medicinal material, boil for 30 minutes, filter, combine three water extracts, concentrate until the relative density is at 60 °C 1.18~1.25, add 95% ethanol until the alcohol content of the liquid is 70%, let stand for 38-60h, take the supernatant and filter until clear, recover the ethanol until the relative density is 1.18~1.25 at 60°C, add 5% gelatin Solution, detanning, add 95% ethanol until the alcohol content is 75%, let it stand for 38-60h, take the supernatant and filter it to clarify, recover the ...

Embodiment 3

[0089] Example 3 Shenkang injection compound preparation preparation method is: take rhubarb 1500g, salvia miltiorrhiza 1500g, the amount of water added for the first time is 10 times the amount of the original medicinal materials, after soaking for 30min, boil for 30min, filter, and the amount of water added for the second time is the amount of the original medicinal materials 8 times the amount of the original medicinal material, boiled for 30 minutes, filtered, the third time added water was 7 times the amount of the original medicinal material, boiled for 30 minutes, filtered, combined three water extracts, concentrated to a relative density of 1.20 to 1.22 at 60 ° C, added 95 % ethanol, until the alcohol content of the medicinal solution is 70%, let it stand for 48-60h, take the supernatant and filter until it is clear, recover the ethanol until the relative density is 1.20-1.22 at 60°C, add 5% gelatin solution, remove tanning, add 95% ethanol, until the alcohol content is...

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Abstract

The invention belongs to a traditional Chinese medicine preparation, in particular relates to a Shenkang injection compound preparation for treating chronic renal failure. The Shenkang injection compound preparation for treating chronic renal failure is prepared from the following bulk pharmaceutical chemicals: 1500g of rheum officinale, 1500g of roots of the red-rooted salvia, 4500g of Astragalus mongholicus and 1500g of red flower. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation to remove pyrogen and sterilize; then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, and carrying out secondary ethanol precipitation and water precipitation to remove pyrogen and sterilize; and finally, combining the two groups of liquid medicine, diluting, carrying out ultrafiltration and fine filtering, and sterilizing to obtain the Shenkang injection compound preparation. The Shenkang injection compound preparation has the advantages of precision in regulating the original ratio, high effectiveness, smaller side effect, high acting speed and high bioavailability. In addition, the product quality and the production efficiency are further improved, and energy consumption is reduced.

Description

technical field [0001] The invention belongs to traditional Chinese medicine injections, in particular to a Shenkang injection compound preparation for treating chronic renal failure and a preparation method thereof. Specifically, it belongs to the field of medicine. Background technique [0002] The original patent 96117626.1 discloses a Shenkang injection and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, the usage amount of Astragalus is high, and astragalus and rhubarb have precipitation reaction, astragalus and salvia miltiorrhiza can also react, if the input amount of astragalus is small in the compatibility of the preparation, it will affect efficacy. Because the precise content of the active ingredient in the intravenous injection solution and the small side effects are crucial. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08
Inventor 吴芳吕延英曹凤君王刚吴护军何宝社梁振辉胡华峰张新卫李锋李涛詹芳
Owner XIAN SHIJISHENGKANG PHARMA IND
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