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Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation

A technology for compound preparations and chronic renal failure, which is applied to medical preparations containing active ingredients, pill delivery, and pharmaceutical formulas, etc. It can solve problems such as large amount of astragalus, precipitation reaction, and no ratio relationship

Active Publication Date: 2013-12-18
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The original patent 200410039418.X discloses a kind of Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, but The amount of astragalus is relatively large, and there is a precipitation reaction between astragalus and rhubarb, and there is also a reaction between astragalus and salvia miltiorrhiza, and the small amount of astragalus in the preparation also affects the efficacy

Method used

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  • Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation
  • Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation
  • Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation

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Effect test

Embodiment 1

[0097] The Shenkang oral solid compound preparation of the present invention is made of the following raw materials: rhubarb 1500g, salvia miltiorrhiza 1500g, astragalus root 4500g and safflower 1500g. The preparation method is as follows: after extracting the raw materials rhubarb and salvia miltiorrhiza according to the proportion of the above formula, alcohol precipitation for one time, detanning, alcohol precipitation for the second time, water precipitation, alcohol precipitation for the third time, and water precipitation for the second time; 1. The safflower is extracted according to the proportion of the above formula, alcohol precipitation again, water precipitation, alcohol precipitation, water precipitation again, ultrafiltration, concentration, and oral solid preparation are made.

Embodiment 2

[0099] Shenkang oral solid compound preparation of the present invention, its preparation method is: take rhubarb, salvia miltiorrhiza, the amount of water added for the first time is 7-12 times of the original medicinal materials, after soaking for 30min, boil for 30min, filter, and the amount of water added for the second time is 7-12 times the amount of the original medicinal material, boil for 30 minutes, filter, add water for the third time to 7-12 times the original medicinal material, boil for 30 minutes, filter, combine three water extracts, concentrate to a relative density of 1.18 at 60 ° C ~1.25, add 95% ethanol until the alcohol content of the liquid is 70%, let it stand for 38-60h, take the supernatant and filter until clear, recover the ethanol until the relative density is 1.18~1.25 at 60°C, add 5% gelatin solution , remove tanning, add 95% ethanol until the alcohol content is 75%, let it stand for 38-60h, take the supernatant, filter and clarify, recover the eth...

Embodiment 3

[0101] The preparation method of Shenkang oral solid compound preparation of the present invention is as follows: take rhubarb and salvia miltiorrhiza, add water for the first time to 10 times the amount of the original medicinal materials, soak for 30 minutes, boil for 30 minutes, filter, and add water for the second time. 8 times the amount, boil for 30 minutes, filter, add water for the third time to 7 times the amount of the original medicinal material, boil for 30 minutes, filter, combine three water extracts, concentrate to a relative density of 1.20-1.22 at 60°C, add 95% ethanol , until the alcohol content of the medicinal solution is 70%, let stand for 48-60h, take the supernatant and filter until clear, recover ethanol until the relative density is 1.20-1.22 at 60°C, add 5% gelatin solution, remove tanning, add 95% Ethanol, until the alcohol content is 75%, let it stand for 48-60h, take the supernatant, filter and clarify, recover the ethanol until the relative density...

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Abstract

The invention relates to a Shenkang oral solid compound preparation for treating chronic renal failure, which is characterized by being prepared from the following bulk pharmaceutical chemicals: 1500g of rheum officinale, 1500g of roots of red-rooted salvia, 4500g of Astragalus mongholicus and 1500g of red flower. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of the red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation; and then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, carrying out secondary ethanol precipitation and water precipitation, and condensing and drying to obtain the oral solid compound preparation. The Shenkang oral solid compound preparation has the advantages of precision in regulating the original ratio, high in content of effective ingredients in the unit volume, few precipitations, small side effect, high acting speed and high bioavailability.

Description

technical field [0001] The invention belongs to traditional Chinese medicine oral preparations, in particular to a Shenkang oral solid compound preparation for treating chronic renal failure and a preparation method thereof. Background technique [0002] The original patent 200410039418.X discloses a kind of Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, but The amount of astragalus is relatively large, and there is a precipitation reaction between astragalus and rhubarb, as well as reaction between astragalus and salvia miltiorrhiza, and the small amount of astragalus in the preparation also affects the efficacy. Because the proportioning relationship of traditional Chinese medicine directly affects the curative effect of the preparation, the accuracy of the presc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/20A61K36/708A61P13/12
Inventor 曹凤君吕延英詹芳赵兴王光建王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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