High-homogeneity bracket used for tissue engineering and preparation method of high-homogeneity bracket

Abstract

The invention discloses a high-homogeneity bracket used for the tissue engineering and a preparation method of the high-homogeneity bracket, belonging to the field of biomedical engineering. The preparation method is a technology comprising the following steps of: enabling a polymer solution or organic solvent to flow through a mould filled with pore-forming agent or a mixture of a polymer and the pore-forming agent under the action of a pressure difference, volatilizing the solvent or removing the pore-forming agent, demoulding and forming. Equipment used in a negative pressure method provided by the invention mainly comprises the four parts, i.e., a forming mould, a Buchner funnel, a rubber stopper and a filter flask. The equipment used in the method is simple and easy to obtain, is easy to implement control and operation, and can be used for preparing columnar and tubular porous brackets of various polymers. Compared with the traditional method, the method provided by the invention has the advantages that the tubular brackets can be directly obtained, the form and the porosity of a hole can be better kept, and the diameters and the wall thicknesses of the porous brackets can be expanded.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and relates to a high-uniformity scaffold for tissue engineering and a preparation method. Background technique [0002] The main medical method for diseased blood vessels with a diameter of no more than 6mm is to use autologous blood vessels as a detour bypass to replace diseased blood vessels, but many patients do not have appropriate and sufficient blood vessels to do repatriation bypasses, so synthetic materials are used to prepare vascular stents. idea. At present, the best construction mode of tubular porous scaffolds for tissue engineering has not yet been established. The traditional method is to weave the material into a film and then cut it into sheets of appropriate size according to needs. When implanted in the body, the sheet membrane is sewn into a tube with sutures, but this method is mostly used for non-degradable polymer materials. Due to the development of tissue engineer...

AI Technical Summary

Problems solved by technology

However, due to the use of heat and solvents in this method, the shape, size and porosity of the pores will be greatly affected, which is not conducive to the adhesion, cultivation and growth of subsequent cells, and the prepared tubular scaffold is prone to cracking at the seams

As for how to directly prepare degradable polymer materials into tubular scaffolds, and then implant them into the body for cell adhesion, there is no literature report yet.

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