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Perfusion medicament for treating milk cow mastitis and preparation method thereof

A cow mastitis and drug technology, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of inability to treat endotoxemia, failure to treat both symptoms and root causes, and affect the treatment effect, to achieve High effective rate, high cure rate, wide antibacterial spectrum effect

Active Publication Date: 2012-12-19
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Inflammation of dairy cow udder is a common and frequently-occurring disease. In this field, a single anti-inflammatory drug has been used for treatment for many years. However, due to the long-term use of a single anti-inflammatory drug treatment, it can not treat both symptoms and root causes, and it is easy to develop drug resistance, which affects the therapeutic effect. Therefore, those skilled in the art provide the medicine of compound prescription perfusion, though this compound medicine has certain advantages, it still cannot treat the endotoxemia that dairy cow udder produces after using antibiotic treatment in the inflammation process, and this endotoxemia Toxemia is due to the bacteria in the blood or the bacteria in the lesion releasing a large amount of endotoxin into the blood, which leads to the acute death of cows during the treatment of mastitis
There is currently no drug available to prevent this endotoxemia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] For example, taking Example 1 as an example, the specific preparation method is as follows:

[0041] ①Put 1 / 10 of 67.5g of liquid paraffin into the batching tank, add 0.2g of prednisolone and 0.9g of flunixin meglumine, and use ultrasonic wave for 40 minutes until the particles are evenly distributed;

[0042] ②Put 1 / 3 of 67.5g of liquid paraffin into the heating tank, heat up to 80°C, add 1.25g of glyceryl monostearate, 5.5g of vaseline, and 0.05g of ethylparaben in sequence, and stir until completely dissolved;

[0043] ③Put the remaining 67.5g of liquid paraffin used in step ① and step ② and the auxiliary materials in step ② into the emulsification tank, mix well, cool down to 30°C, and then put the mixed raw materials in step ② into the emulsification tank After stirring until uniformly dispersed, 2.6 g of cefquinome sulfate was added, and then stirred until uniformly distributed to obtain an infusion medicine for treating cow mastitis.

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PUM

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Abstract

The invention discloses a perfusion medicament for treating milk cow mastitis and a preparation method thereof. The perfusion medicament is prepared from the following raw materials by weight: 0.9-4.3g of cefquinome sulphate, 0.15-0.25g of prednisolone, 0.5-1.3g of flunixin meglumine, 1-1.5g of glycerin monostearate, 3-8g of Vaseline, 0.05g of ethylparaben and 65-70g of whiteruss. The preparationmethod comprises the following specific steps of: (1) putting one tenth of the liquid paraffin into a burdening tank in a certain weight ratio; (2) adding one third of the liquid paraffin into a heating tank; and (3) putting the rest of the liquid paraffin left after the steps (1) and (2) and auxiliary materials in the step (2) into an emulsifying tank, adding 0.9-4.3g of cefquinome sulfate in a certain weight ratio, and stirring till uniform distribution to obtain the perfusion medicament for treating milk cow mastitis. The perfusion medicament has the advantages of no induction of endotoxemia in a milk cow mastitis treating process, remarkable curative effect on mastitis and freeness from medicament tolerance.

Description

technical field [0001] The invention relates to veterinary medicine, which is an infusion medicine for treating cow mastitis and a preparation method thereof. Background technique [0002] Inflammation of dairy cow udder is a common and frequently-occurring disease. In this field, a single anti-inflammatory drug has been used for treatment for many years. However, due to the long-term use of a single anti-inflammatory drug treatment, it can not treat both symptoms and root causes, and it is easy to develop drug resistance, which affects the therapeutic effect. Therefore, those skilled in the art provide the medicine of compound prescription perfusion, though this compound medicine has certain advantages, it still cannot treat the endotoxemia that dairy cow udder produces after using antibiotic treatment in the inflammation process, and this endotoxemia Toxemia is caused by the bacteria in the blood or the bacteria in the lesion releasing a large amount of endotoxin into the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61K31/546A61K31/44A61P31/04A61P15/14
Inventor 李成应王海挺吴连勇田玉柱张智德董菊红
Owner QILU ANIMAL HEALTH PROD