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Method for building a water maze spatial learning and memory model for tree shrews

A technology of learning memory and establishing methods, which is applied in the field of building tree shrew models of water maze space learning and memory, and can solve problems such as restrictive effects and limited data reference

Active Publication Date: 2012-06-20
INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

Therefore, the degree of consistency between the structure and function of the brain structure and function of experimental animals, especially the structure and function of the hippocampus, determines the role of the water maze experiment in medical biology. In all the Morris water maze experiments reported and used in the literature, the one that has been successfully applied Both are rat and mouse Morris water maze spatial learning and memory models. Since rats and mice are low-level rodents, their brain structure and function are far from those of humans, and the data obtained from the water maze spatial learning and memory model are limited. Therefore, the role of this model in various fields is greatly limited

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  • Method for building a water maze spatial learning and memory model for tree shrews
  • Method for building a water maze spatial learning and memory model for tree shrews
  • Method for building a water maze spatial learning and memory model for tree shrews

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Experimental program
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Embodiment Construction

[0033] 1. Screening of animals before the experiment:

[0034] The tree shrew used in the experiment is the first generation of Chinese Burmese tree shrew self-propagating in the laboratory. It is 12 months old and weighs 110g-120g. Before the experiment, the tree shrew has been kept in a quiet environment with normal light rhythm. Pretreatment with pick and place. From 13 male tree shrews, 10 tree shrews that started to swim within 10 seconds, with a swimming speed ≥ 15cm / s were selected, and the offspring tree shrews with a total swimming time of 30 seconds were selected; selected from 15 female tree shrews 10 tree shrews with a swimming speed ≥ 15cm / s that started to swim within 10s after being placed in the water maze experimental pool were screened for the first generation of tree shrews whose swimming time was 30s.

[0035] 2. Experimental device preparation

[0036] The water maze experiment was a circular pool with a diameter of 160 cm and a height of 50 cm as requir...

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Abstract

A method for building a water maze spatial learning and memory model for tree shrews includes: screening tree shrews before test, preparing experimental facilities, carrying out experimental operations and determining model building indexes. The model building indexes determined in the method includes that accuracy is more than 90% in a place navigation test, and an average latency between 20s and 25s serves as a standard of a spatial learning model built by a tree shrew in the water maze test; and in a space exploration test, a spatial memory model built by the tree shrew in the water maze test is determined according to significant difference of ratio of time spent in the target quadrant and crossing times before and after training.

Description

technical field [0001] The invention relates to a method for establishing a novel experimental animal behavior model in the field of life sciences, in particular to a method for establishing a water maze space learning and memory tree shrew model. Background technique [0002] The Morris water maze test is a relatively objective evaluation method for spatial learning and memory functions recognized in the world. It was designed by Richard Morris in 1981 and applied to the study of the brain mechanism of learning and memory. It is an animal that can learn to swim in a water tank and find hidden water In the experimental method of avoiding the platform, since there are no accessible clues to identify the position of the platform, the effective positioning ability of animals needs to use structures outside the water tank, such as some simple graphic signs attached to the water maze box, as spatial positioning clues. [0003] In recent years, the water maze experiment has been ...

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Application Information

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IPC IPC(8): A01K15/02
Inventor 孙晓梅罕园园陆彩霞王文广江勤芳仝品芬
Owner INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
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