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Method for detecting tanshinone compounds in compound salvia tablets

A technology of compound danshen tablets and tanshinone, which is applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problems of poor universality of the method, insufficient to fully reflect the quality of compound danshen tablets, and few monitoring indicators.

Active Publication Date: 2012-06-20
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content determination of tanshinone compounds in Compound Danshen Tablets in the 2010 edition of "Pharmacopoeia of the People's Republic of China" only controlled tanshinone II A For one ingredient, there are few monitoring indicators, which are not enough to fully reflect the quality of Compound Danshen Tablets
At present, there are many literature reports on the multi-index content determination method of tanshinone compounds in Compound Danshen Tablets, but there are deficiencies such as unreasonable selection of detection indicators, rare reference substances, and poor universality of the established method.

Method used

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  • Method for detecting tanshinone compounds in compound salvia tablets
  • Method for detecting tanshinone compounds in compound salvia tablets
  • Method for detecting tanshinone compounds in compound salvia tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] According to the specification requirements of Compound Danshen Tablets in the 2010 edition of the Pharmacopoeia of the People's Republic of China, 20 batches of samples of Compound Danshen Tablets were taken for determination.

[0098] Determine according to high performance liquid chromatography (Appendix VI D of "Pharmacopoeia of the People's Republic of China" 2010 edition).

[0099] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; methanol-water (73:27) is used as mobile phase; detection wavelength is 248nm. The number of theoretical plates according to Tanshinone II A The calculation should be no less than 2000.

[0100] Preparation of standard solution: take tanshinone compound reference substance, add methanol to dissolve it; in μg / mL, the mass volume ratio of dihydrotanshinone I reference substance to methanol is 10:1; cryptotanshinone reference substance, tanshinone I reference substance or Tanshino...

Embodiment 2

[0131] According to the specifications of Compound Danshen Tablets in the 2010 edition of the Pharmacopoeia of the People's Republic of China, 3 batches of Compound Danshen Tablets were taken for determination.

[0132] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; methanol-water (70:30) is used as mobile phase; detection wavelength is 254nm. The number of theoretical plates according to Tanshinone II A The calculation should be no less than 2000.

[0133] Preparation of standard solution: Take tanshinone compound reference substance and dissolve it in methanol; in μg / mL, the mass volume ratio of dihydrotanshinone I reference substance to methanol is 8:1; cryptotanshinone reference substance, tanshinone I reference substance or Tanshinone II A The mass-to-volume ratio of the reference substance to methanol was 60:1.

[0134] Preparation of reference substance solution: take Tanshinone II A Take an appropriate a...

Embodiment 3

[0162] According to the specification requirements of Compound Danshen Tablets in the 2010 edition of the Pharmacopoeia of the People's Republic of China, 5 batches of Compound Danshen Tablets were taken for content determination.

[0163] Chromatographic conditions and system suitability test: octadecylsilane bonded silica gel is used as filler; methanol-water (75:25) is used as mobile phase; detection wavelength is 244nm. The number of theoretical plates according to Tanshinone II A The calculation should be no less than 2000.

[0164] Preparation of standard solution: take tanshinone compound reference substance, add methanol to dissolve it; in μg / mL, the mass volume ratio of dihydrotanshinone I reference substance to methanol is 12:1; cryptotanshinone reference substance, tanshinone I reference substance or Tanshinone II A The mass-to-volume ratio of the reference substance to methanol was 40:1.

[0165] Preparation of reference substance solution: take Tanshinone II A...

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Abstract

The invention relates to the field of drug compound detection, in particular to a method for detecting tanshinone compounds in compound salvia tablets. A plurality of components of the same type including dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA can be simultaneously detected by detecting the index component of the tanshinone IIA. The method is simple and convenient, is fine in universality and can be used for more completely reflecting the quality of the compound salvia tablets.

Description

technical field [0001] The invention relates to the field of detection of pharmaceutical compounds, in particular to a method for determining tanshinone compounds in compound danshen tablets. Background technique [0002] Compound Danshen Tablets is a commonly used cardiovascular and cerebrovascular drug in clinical practice. It is a traditional Chinese medicine preparation made of Danshen, Panax notoginseng and borneol as raw materials and auxiliary materials. It can promote blood circulation, remove blood stasis, regulate qi and relieve pain. Compound Danshen Tablets are recorded in the 2010 edition of the "Pharmacopoeia of the People's Republic of China" and are divided into three specifications. The first specification is film-coated small tablets, each weighing 0.32g, which is equivalent to 0.6g decoction pieces; the second specification is film-coated large tablets. Each piece weighs 0.8g, which is equivalent to 1.8g of decoction pieces; the third specification is suga...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 吴笛臧忠良王德勤覃仁安李楚源李兰芳
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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