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Sustained release premixing agent

A gentle and uniform mixing technology, which is applied in the field of slow and controlled release premixes, can solve the problems of poor uniformity, large batch-to-batch differences in the swelling degree of mixed excipients, large fluctuations in drug release rates, etc., and achieve the effect of stable release.

Active Publication Date: 2014-03-05
天津红日爱乐意药用辅料有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The disadvantages of the current sustained-release solid preparations are that the drug release rate fluctuates greatly and the therapeutic effect is unstable.
The main reasons are: 1. The uniformity of HPMC, the main controlled-release material in the excipients, is poor, resulting in large differences in the swelling degree of the mixed excipients within and between batches; 2. The difference in the viscosity of HPMC itself leads to large differences in the swelling degree of the mixed excipients

Method used

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Examples

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Embodiment Construction

[0017] Below in conjunction with the examples, the present invention is further described, the following examples are illustrative, not limiting, and the protection scope of the present invention cannot be limited by the following examples.

[0018] A slow and controlled release premix, raw materials and preparation method are as follows:

[0019] The raw materials are HPMC and MCC, and the ratio of parts by weight is HPMC:MCC=50:50.

[0020] The preparation method is:

[0021] Mix HPMC and MCC at a ratio of 1:1, add purified water under the condition of stirring and chopping in a high-speed granulator, and the prepared soft material is dried at 60 degrees Celsius, crushed, sieved, and collected into 80-120 mesh Between the powder, that is.

[0022] The sustained and controlled release premix can be further mixed with active ingredients of pharmaceutical excipients and then pressed into tablets. Tablet after mixing.

[0023] Preparation Examples:

[0024] Examples of prep...

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Abstract

The invention relates to a sustained release premixing agent. The weight part ratio of hydroxypropyl methycellulose to microcrystalline cellulose is (10-80):(90-20). The sustained release premixing agent is obtained by physically mixing the hydroxypropyl methycellulose and the microcrystalline cellulose. The mixture obtained in the invention has certain granularity, fluidity, compressibility and water swellability, and most medicaments can be released at a required speed.

Description

technical field [0001] The invention belongs to the field of sustained release solid preparations, in particular to a sustained and controlled release premix. Background technique [0002] Sustained-release solid preparations include tablets and pellets. Cellulose ether components are usually used as sustained- and controlled-release materials, and then mixed with other pharmaceutical excipients such as microcrystalline cellulose and lactose. Made into tablets or pellets. The market demand for solid sustained and controlled release preparations is large, the technical content is high, the production is difficult, and the domestic technical level is lower than that of western developed countries. [0003] The disadvantages of the current sustained-release solid preparations are that the drug release rate fluctuates greatly and the therapeutic effect is unstable. The main reasons are: 1. The poor uniformity of HPMC, the main controlled-release material in the excipients, lea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K9/22
Inventor 李军
Owner 天津红日爱乐意药用辅料有限公司