Porous rack with spherical pores and its molding prepn process

A porous scaffold and spherical technology, which is applied in the field of polymer materials and biomaterials, can solve the problems of difficult mechanical properties of scaffolds, unfavorable molding, and low porosity of scaffolds, and achieves a simple and practical preparation method, which is conducive to large-scale production, good mechanical properties

Inactive Publication Date: 2004-04-07
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Three-dimensional printing is carried out at room temperature, but the pore size of the obtained scaffold is relatively small, and the mechanical properties and molding precision still need to be further improved (Cima et al, J.Biomater.Sci.Polym.Ed., 1996, 8(1): 63 -75)
But its disadvantage is that the porosity of the bracket is low, usually less than 80%, and the current shape forming accuracy needs to be improved
However, since the hole-forming method of Ma et al. is not very favorable for forming, the obtained scaffold is thinner, and it is not easy to obtain a scaffold with better mechanical properties.

Method used

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  • Porous rack with spherical pores and its molding prepn process
  • Porous rack with spherical pores and its molding prepn process
  • Porous rack with spherical pores and its molding prepn process

Examples

Experimental program
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Effect test

Embodiment 1

[0054] Example 1, first prepare spherical paraffin particles. Add 1g of gelatin and 20g of paraffin to 400mL of deionized water, raise the temperature to 80°C and stir evenly under 400rpm mechanical stirring, then add 300mL of ice water to quench the microspheres to keep the spherical shape. Filtered, washed several times with deionized water, dried and then sieved into different fractions of paraffin particles with different standard sieves (see figure 1 ), and stored dry for later use.

[0055] Dissolve 0.5g of PLGA85 / 15 with a molecular weight of 300,000 in 8mL of acetone, add 9.5g of spherical paraffin particles with a particle size of 355-450μm into the solution, stir evenly, and partially volatilize the solvent to make the polymer solution—the porogen The particle mixture becomes a paste; press the mixture into a pre-designed silicone rubber mold (diameter 1cm, height 1cm), apply appropriate pressure and keep it for 30 minutes; after demolding, a polymer solution with t...

Embodiment 2

[0056] Example 2, 0.45g of PLGA85 / 15 with a molecular weight of 300,000 was dissolved in 8mL of acetone, 2.55g of paraffin spherical particles, and the particle diameter was 810-900 μm. Others were the same as in Example 1, and the pores of the porous support were interconnected (see Figure 4 ), the porosity is 89.8%, and the compressive strength is 7.1MPa.

Embodiment 3

[0057] Example 3, 0.6g of PLGA85 / 15 with a molecular weight of 300,000 was dissolved in 10mL of acetone, 1.4g of paraffin spherical particles, the particle size was 355-450μm, the others were the same as in Example 1, and the porosity of the prepared porous scaffold was 78.4%. , The compressive strength is 15.4MPa.

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Abstract

The present invention belongs to the field of polymer material and biological material technology, and is especially one porous rack with spherical pores and its molding preparation process. The 3D porous rack is prepared with polymer material as base material and through molding at normal temperature. The simple process may be used in preparing both rack with simple and regular outer appearance and rack with complicated and irregular outer appearance. The prepared porous rack may be relatively thick and has regular spherical pore structure of porosity over 90%, and the pores are communicated mutually and homogeneously distributed. The rack has high mechanical strength, and is suitable as 3D porous cell rack in tissue engineering and in other application fields.

Description

technical field [0001] The invention belongs to the technical field of macromolecular materials and biomaterials, and in particular relates to a macromolecular spherical porous support and a preparation method thereof by mold pressing at normal temperature. technical background [0002] Porous scaffolds or porous foams can be widely used in many fields such as tissue engineering scaffolds, cell culture carriers, drug controlled release carriers, wound dressings, separation membranes and filter materials, chromatography column fillers, packaging and insulating materials. [0003] The birth of tissue engineering, which combines cells and porous scaffolds to prepare engineered tissues and organs, is a major advancement in traditional tissue and organ transplantation. In tissue engineering, porous scaffolds play an extremely important role in the cultivation and expansion of cells and the formation of final tissues or organs. Biodegradable polymer materials are relatively easy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61L27/56A61L33/08C08J9/26
Inventor 丁建东张俊川吴林波
Owner FUDAN UNIV
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