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Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof

A technology of nanofibers and nanofiber membranes, which is applied in the fields of spinning solution preparation, medical science, heating/cooling fabrics, etc. It can solve the problems of single chemical composition of nanofibers, limited mechanical properties, and less than 20% of the artificial bone market. Achieve good biological activity and biocompatibility, high mechanical strength

Inactive Publication Date: 2013-12-11
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far bone repair still mainly uses autologous bone and allogeneic bone, and artificial bone accounts for less than 20% of the bone repair material market
However, the mechanical properties of these nanofibers are limited due to their single chemical composition, which is either composed of inorganic calcium phosphate or organic collagen.

Method used

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  • Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof
  • Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof
  • Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1 Preparation of disordered calcium phosphate nanofiber membrane

[0061] Add 5 grams of Ca(NO 3 ) 2 ·4H 2 O and 2 grams (NH 4 ) 2 HPO 4 Add to 100 ml of ethanol and water in a 4:1 mixed solvent to form a solution, and add hydrochloric acid to adjust the pH to 3, stir for 24 hours; add 3 grams of polyvinylpyrrolidone with a weight average molecular weight of 1,300,000 to the above solution Continue stirring for 1 hour to obtain the hydroxyapatite precursor electrospinning solution; transfer the electrospinning solution to the electrospinning container 1 containing the spinning solution in the special electrospinning equipment with the piston type input pump 2 , The electrospinning solution at the spinning port 3 is affected by the high-voltage electric field to form a liquid electrospinning jet 7. The jet is continuously refined in the electric field, and the solvent in the jet evaporates quickly, and finally on the flat receiving electrode plate 5. The cured ultra...

Embodiment 2

[0062] Example 2 Preparation of axial array calcium phosphate nanofiber membrane

[0063] In this example, the axial receiving drum 6 in the special equipment is used to receive the electrospinning nanofibers (in this case, the flat receiving electrode plate 5 can be replaced with the axial receiving drum 6), and the rotating speed of the drum is 2000 revolutions per minute. The collected axial array electrospun fibers were put into a box-type resistance furnace and fired at 1000°C for 6 hours to remove organic components. The other preparation conditions were the same as in Example 1. As a result, axial array hydroxyapatite nanofiber membranes were obtained , Its average diameter is 260 nanometers, such as image 3 Shown.

Embodiment 3

[0064] Example 3 Preparation of disordered calcium phosphate nanofiber membrane

[0065] Use Ca(NO 3 ) 2 ·4H 2 O: (NH 4 ) 2 HPO 4 ) The molar ratio is 1.5, and other preparation conditions are the same as in Example 1, to obtain a tricalcium phosphate nanofiber membrane with an average diameter of 350 nm.

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Abstract

The invention discloses a calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and a preparation method thereof. A calcium phosphate nanometer fiber film serves as a nanometer structural unit and combines with collagen to form the compound nanometer artificial bone; or a collagen nanometer fiber film serves the nanometer structural unit and combines with the calcium phosphate to form the compound nanometer artificial bone. The preparation method comprises the steps of preparing the calcium phosphate nanometer fiber film and collagen nanometer fiber film by using a static spinning device; and alternatively combining with collagen or calcium phosphate after taking the calcium phosphate nanometer fiber film or collagen nanometer fiber film as the nanometer structural unit to form the calcium phosphate-collagen nanometer fiber compound nanometer artificial bone. The compound nanometer artificial bone disclosed by the invention at least comprises one nanometer fiber in calcium phosphate or collagen, has biologic activity, biological compatibility and biomechanic intensity and can be used for repairing defects parts of weight bearing bones, including skulls, limb-stem bones, orofacial bones, vertebral columns and the like and serving as gradient materials to repair the connection parts of cartilages and bones.

Description

Technical field [0001] The invention relates to a biomedical material and its preparation technology, in particular to a nano artificial bone composited with calcium phosphate nanofibers and collagen nanofibers, and a method for preparing the composite nano artificial bone, belonging to the field of biomedical materials. Background technique [0002] Bone-joint system damage is a major disease threatening human health. 80% of its patients need to use biomedical materials for treatment. Orthopedic biomedical materials and implanted devices have accounted for 37% of the high-tech biomaterials market. However, bone repair still mainly uses autogenous bone and allogeneic bone so far, and artificial bone accounts for less than 20% of the bone repair material market. However, the source of autologous bone and allogeneic bone is limited, and there may be risks of immune rejection and disease infection. Therefore, the development of artificial bone has always been the main direction for ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/24A61L27/12D04H1/42D04H1/4209D04H1/728D06C7/00D01D1/02
Inventor 洪友良王哲张兴栋
Owner SICHUAN UNIV
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