Preparation method of chromium methionine chelate

A technology of chromium methionine and chelate, which is applied in the field of preparation of chromium methionine chelate, can solve the problems of no use value, inability to realize continuous production, long operation time, etc., and achieve high reliability of equipment industrialization, crystal form and particle size Good, short operating time results

Active Publication Date: 2014-07-02
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method takes a long time to operate, and the method of adjusting the pH by dropping sodium hydroxide solution to make the product precipitate has no industrial value and cannot realize continuous production

Method used

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  • Preparation method of chromium methionine chelate
  • Preparation method of chromium methionine chelate
  • Preparation method of chromium methionine chelate

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Experimental program
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Effect test

Embodiment 1

[0032] 4.5284gD, L-methionine (0.03mol), sodium hydroxide 1.2018g (0.03mol) and absolute ethanol were stirred and dissolved to obtain solution 1. 2.6914 g (0.01 mol) of chromium chloride and absolute ethanol were stirred and dissolved to obtain solution 2, to which solution 1 was added. React at 90°C for 0.5 hours under normal pressure. After the completion of the reaction, cooling, filtering, washing, and drying were performed to obtain a purple-red crystalline powder with a yield of 86.6% of chromium methionine chelate.

[0033] The synthesized product was qualitatively characterized by ultraviolet and infrared spectroscopy, see figure 2 and image 3 . The content of trivalent chromium in the product is determined by ICP method, and the content of methionine is determined by pre-column derivatization high performance liquid chromatography. The trivalent chromium content is 10.09% and the methionine content is 89.27%

Embodiment 2

[0035] 3.0143g D,L-methionine (0.02mol), potassium hydroxide 1.122g (0.02mol) and 10% ethanol solution were stirred and dissolved to obtain solution 1. 2.6921 g (0.01 mol) of chromium chloride and a 10% ethanol solution were stirred and dissolved to obtain solution 2, to which solution 1 was added. React at 30°C for 3 hours under normal pressure. After the completion of the reaction, cooling, filtering, washing, and drying were performed to obtain a purple crystalline powder. The yield of chromium methionine chelate was 84.8%. The content of trivalent chromium is 14.82%, and the content of methionine is 85.04%

Embodiment 3

[0037] The experimental procedure is the same as above, and the reaction conditions are as follows: D, L-methionine 1.5072g (0.01mol), sodium carbonate 0.5318g (0.005mol) chromium chloride 2.6918g (0.01mol), 10% ethanol solution, normal pressure, 90℃, React for 3 hours. The yield of methionine chromium chelate is 92.6%. The trivalent chromium content is 25.91%, and the methionine content is 74.02%.

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Abstract

The invention relates to a preparation method of a chromium methionine chelate. The preparation method provided by the invention comprises that main raw materials of D,L-methionine and one or more inorganic chromic salts undergo a reaction in the presence of an alcohol solution as a reaction medium at a reaction temperature of 30 to 90 DEG C for 0.5 to 3 hours to produce the chromium methionine chelate. The preparation method provided by the invention adopts the easily available raw materials, has a low production cost, allows mild reaction conditions and realizes energy saving and consumption reduction. The preparation method can be enlarged easily, is convenient for regulation and control and has good industrial application prospects.

Description

Technical field [0001] The invention relates to a preparation method of a chelate, in particular to a preparation method of a methionine chromium chelate. Background technique [0002] Cr(III) is an important trace element that maintains normal sugar metabolism and lipid metabolism in mammals, and it is one of the trace elements necessary for mammalian nutrition. In 1959, Schwarz and Mertz proposed the glucose tolerance factor (GTF) hypothesis (Schwarz K, Mertz W.Chromium(III) and the glucose tolerance factor[J].Archs Biochem.Biophys.1959, 86:292.), and pointed out three Valence chromium is the active ingredient of GTF. Without Cr(III), GTF has no biological activity. Since then, a large number of studies have shown that trivalent chromium has a very important effect on the sugar metabolism and lipid metabolism of mice, chickens, ducks and other domestic animals, pigs, cattle, sheep and other domestic animals and humans and other mammals. Since the 1990s, trivalent chromium has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C323/58C07C319/20
Inventor 肖清贵唐海燕徐红彬张懿
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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