Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A cardiovascular and cerebrovascular disease, compound technology, applied in the field of medicine, can solve the problems that patients cannot bear and limit clinical application
CN102526065BInactive Publication Date: 2014-08-13XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XIAN LIBANG ZHAOXIN BIOTECH CO LTD
Publication Date
2014-08-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a compound injection preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The preparation method comprises the following steps of: taking alprostadil and edaravone as active pharmaceutical ingredients, and compounding the alprostadil and the edaravone according to a certain ratio to form a certain injection preparation. With the adoption of the compound injection preparation, heart vessels or brain vessels can be effectively dilated, the chronic arterial occlusive diseases, caused by thromboangiitis obliterans, diabetes and the like, can be effectively treated, and meanwhile, the pain generated in the conventional injection of an alprostadil preparation can be remarkably abated due to the adoption of the compound preparation of the alprostadil and the edaravone.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a compound injection preparation with edaravone and alprostadil as main active pharmaceutical ingredients and a preparation method thereof. The compound preparation can effectively treat cardiovascular and cerebrovascular diseases. Background technique

[0002] Alprostadil has another name called prostaglandin E1 (prostaglandin E1, PGE1), and its chemical name is: 11a, 15 (S)-bishydroxyl-9-keto-13-antiprostenic acid, and its chemical structural formula is as follows:

[0003]

[0004] Alprostadil is an endogenous physiologically active substance with various physiological and pharmacological effects. It can expand blood vessels, inhibit platelet aggregation, thromboxane A2 generation, atherosclerotic lipid plaque formation and immune complexes, and can expand peripheral and coronary vessels, reduce gastric juice secretion, and stimulate small intestine and uterine peristalsis. ...

Claims

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