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Absorbable haemostatic material prepared based on rat tail collagen and preparation method of same

A technology of collagen and hemostatic materials, applied in the direction of absorption pads, peptide/protein components, blood diseases, etc., can solve the problems of body allergies, non-absorbable hemostatic patches, poor hemostatic effect, etc., to prevent intestinal adhesion, promote wound healing, Avoid the effect of rising costs

Inactive Publication Date: 2012-07-04
广东省医学实验动物中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the disadvantages of the existing hemostatic patch, such as non-absorbable, easy to cause body allergy, poor hemostatic effect, etc., to provide a human body absorbable, biocompatible, The hemostatic material with fast hemostatic effect, the invention also provides the preparation method of this hemostatic material

Method used

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  • Absorbable haemostatic material prepared based on rat tail collagen and preparation method of same
  • Absorbable haemostatic material prepared based on rat tail collagen and preparation method of same

Examples

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Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: Preparation of hemostatic material

[0026] 1. Select polyvinyl alcohol and chitosan that can work together with rat tail collagen as auxiliary materials. The weight ratio of each material is rat tail collagen: polyvinyl alcohol: chitosan is 1%: 0.2%: 0.2%. The balance is water.

[0027] 2. Dissolve the mixed material in sterile water and pour it into a small culture plate, pre-freeze at -40°C for 2 hours, then transfer it to a -80°C ultra-low temperature refrigerator for 4 hours, and then transfer it to a vacuum freeze dryer to store the composite material at -4 The composite freeze-dried hemostatic material can be obtained by freeze-drying at ℃ for 10 hours. Co60 radiation sterilization, dry storage. The freeze-dried material can be directly used for hemostasis of various wounds.

Embodiment 2

[0028] Embodiment 2: Preparation of hemostatic material

[0029] 1. Select polyvinyl alcohol and chitosan that can work together with rat tail collagen as auxiliary materials. The weight ratio of each material is rat tail collagen: polyvinyl alcohol: chitosan is 5%: 2%: 1%, and the balance is water.

[0030] 2. Dissolve the mixed material in sterile water and pour it into a small culture plate, pre-freeze at -20°C for 7 hours, then transfer it to a -80°C ultra-low temperature refrigerator for 8 hours, and then transfer it to a vacuum freeze dryer to store the composite material at -4 The composite freeze-dried hemostatic material can be obtained by freeze-drying at ℃ for 30 hours. Co60 radiation sterilization, dry storage. The freeze-dried material can be directly used for hemostasis of various wounds.

Embodiment 3

[0031] Embodiment 3: Preparation of hemostatic material

[0032] 1. Select polyvinyl alcohol and chitosan that can work together with rat tail collagen as auxiliary materials. The weight ratio of each material is rat tail collagen: polyvinyl alcohol: chitosan is 10%: 5%: 2%, and the balance is water.

[0033] 2. Dissolve the mixed material with sterile water and pour it into the culture plate, pre-freeze at 0°C for 12 hours, then transfer to -80°C ultra-low temperature refrigerator for 12 hours, and then transfer the composite material to a vacuum freeze dryer at -4°C After 60 hours of freeze-drying, the composite freeze-dried hemostatic material can be obtained. Co60 radiation sterilization, dry storage. The freeze-dried material can be directly used for hemostasis of various wounds.

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Abstract

The invention relates to an absorbable haemostatic material prepared based on rat tail collagen and a preparation method of the absorbable haemostatic material. The absorbable haemostatic material is prepared from the rat tail collagen, polyvinyl alcohol and chitosan with respective weight percentages of 1%-10%, 0.2%-5% and 0.2%-2%, and the balance of water by a freeze-drying technology. The haemostatic material of the invention is mainly prepared with the rat tail collagen; compared with disadvantages that the conventional haemostatic material is unabsorbable, body allergy is easily caused, the haemostatic effect is poor, and the like, the haemostatic material prepared by the invention is absorbable in a human body, good in biocompatibility, quick in hemostasis and strong in hydrophilia; platelet aggregation can be activated to form a thrombus, thereby promoting the plasma agglomeration and stopping blood flowing; and a specific region on the surface of the collagen can be bound with glycoprotein similar to fibronectin on the surface of a cell, so that the haemostatic material has a function of preventing intestinal adhesion.

Description

【Technical field】 [0001] The invention relates to a product prepared based on rat tail collagen, an absorbable hemostatic material and a preparation method thereof. 【Background technique】 [0002] Collagen is a major component of support structures in vertebrates and invertebrates. In the human body it is the most important protein of skin, tendon, cartilage, bone and connective tissue. Collagen accounts for one-third of the total protein in the human body. No matter which animal or tissue it comes from, collagen has many common characteristics. About one-third of the amino acid composition is glycine, and there are proline and hydroxyproline. Collagen is divided into more than 20 subtypes according to the difference of its genetic molecular structure and genetic gene. But the most common ones are type I, II, and III collagen, that is, interstitial collagen. Among them, type I is the most abundant and of good quality. Type I collagen is very widely distributed and is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/24A61L15/64A61K38/39A61K9/12A61P7/04A61P41/00A61P17/02C08J9/28
Inventor 钟志勇任海涛唐小江严家荣黄红坤黄小红黄小琼武昕
Owner 广东省医学实验动物中心
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