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Milrinone injection

A technology of injection and milrinone, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problem that milrinone infusion can not adapt to and meet the requirements of clinical medication, increase the light level of drugs, and affect the quality of drugs. Stability and other issues, to avoid the increase of edema, good clinical effect, reduce the effect of light

Active Publication Date: 2015-04-15
NEW FOUNDER HLDG DEV LLC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This prescription belongs to large infusion preparation, which has the following disadvantages in practical application: the solvent of large infusion is sodium chloride solution, which contains 872mg sodium chloride per 100ml, due to the adverse reaction caused by the "extra added" sodium salt in large infusion It brings additional safety risks to patients, especially for patients with cardiac insufficiency and heart failure. The principle of treatment includes the regulation of "restricting sodium and salt intake", because patients with heart failure generally have water and sodium. The clinical manifestation of retention, and edema is aggravated with the aggravation of heart failure
Large infusions also have disadvantages such as inconvenient transportation, increasing the light level of the drug, which affects the stability of the drug, etc.
Therefore, the milrinone infusion solution disclosed in Chinese patent 200410030826.9 cannot adapt to and meet the needs of clinical medication

Method used

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  • Milrinone injection
  • Milrinone injection

Examples

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Comparison scheme
Effect test

Embodiment 1

[0026] Milrinone 10g

[0027] Lactic acid 11.2 grams

[0028] Sodium chloride 8.8 grams

[0029] Water for injections to a total volume of 10 liters

[0030] Weigh milrinone, add 6 liters of water for injection, stir, adjust the pH value of the solution to 3.0 with lactic acid, continue to stir until fully dissolved, add sodium chloride, stir until fully dissolved, add water for injection to a total volume of 10 liters, and mix well , filtered through a microporous membrane, filled with 2000 bottles, and sterilized.

Embodiment 2

[0032] Milrinone 10g

[0033] Lactic acid 9.6 grams

[0034] Sodium chloride 8.5 grams

[0035] Water for injections to a total volume of 10 liters

[0036] Weigh milrinone, add 6 liters of water for injection, stir, adjust the pH value of the solution to 3.5 with lactic acid, continue to stir until fully dissolved, add sodium chloride, stir until fully dissolved, add water for injection to a total volume of 10 liters, and mix well , filtered through a microporous membrane, filled with 2000 bottles, and sterilized.

Embodiment 3

[0038] Milrinone 10g

[0039] Lactic acid 12.9 grams

[0040] Sodium chloride 9.2 grams

[0041] Water for injections to a total volume of 10 liters

[0042] Weigh milrinone, add 6 liters of water for injection, stir, adjust the pH value of the solution to 2.8 with lactic acid, continue to stir until fully dissolved, add sodium chloride, stir until fully dissolved, add water for injection to a total volume of 10 liters, and mix well , filtered through a microporous membrane, filled with 2000 bottles, and sterilized.

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Abstract

The invention provides milrinone injection and a preparation method of the milrinone injection, and belongs to the technical field of chemical medicine preparations. The milrinone injection provided by the invention has the advantages that the stability is good, the milrinone relevant substance content is low, and the clinic use effect is good.

Description

technical field [0001] The invention relates to a milrinone injection and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Milrinone is a cardiotonic drug, a phosphodiesterase inhibitor, and a substitute for amrinone, but its effect is 10 to 30 times stronger than that of amrinone, and it is better tolerated. Both oral and intravenous milrinone are effective, but the adverse reactions are serious when taken orally. Milrinone has both positive inotropic and vasodilation effects. The positive inotropic effect of this product is mainly through the inhibition of phosphodiesterase, which increases the concentration of cyclic adenosine monophosphate (CAMP) in myocardial cells, increases intracellular calcium, strengthens myocardial contractility, and increases cardiac output. Its vasodilator effect may be caused by directly acting on small arteries, thereby reducing cardiac preload and afterload, reducin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/444A61P9/04
Inventor 兰静丁继军
Owner NEW FOUNDER HLDG DEV LLC
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