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Medicine for treating vascular dementia and preparation method thereof

A technology for vascular dementia and drugs, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of lack of animal models, safety cannot be estimated, and the advantages of traditional Chinese medicine are not particularly prominent.

Inactive Publication Date: 2012-07-11
WUHAN HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic advantages of traditional Chinese medicine are not particularly prominent. In addition, there is still a lack of recognized animal models of vascular dementia, and the safety cannot be estimated.

Method used

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  • Medicine for treating vascular dementia and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Composition: Tianma 300g, Polygonatum 500g, Ligustrum lucidum 500g, Earthworm 150g, Leech 50g, Shichangpu 300g.

[0035] Preparation:

[0036] A, according to the above weight ratio, take the raw material medicine for subsequent use;

[0037] B, place earthworm, leech, calamus calamus in drying room, pulverize after 72 hours of drying at 60 ℃, cross 100 mesh sieves, mix and make medicine fine powder (I);

[0038] C. Gastrodia elata, Polygonatum, and Ligustrum lucidum are placed in a 100-liter sandwich pot, soaked in water for 0.5 hours, add water to 20 liters, decoct for 1.5 hours, and take 12 liters of juice; add 15 liters of water, decoct for 1 hour, and take 6 liters of juice , the combined filtrate decocted twice was left standing for 1h, concentrated to a relative density of 1.38, and 0.5kg of clear cream (II) was obtained;

[0039] D. Place the clear paste (II) prepared in step C in a microwave vacuum drier, set the temperature at 60°C, negative pressure at 0.08...

Embodiment 2

[0042] Composition: Gastrodia elata 10g, Polygonatum 10g, Ligustrum lucidum 10g, Earthworm 3g, leech 1g, Shichangpu 6g.

[0043] Preparation:

[0044] A, according to the above weight ratio, take the raw material medicine for subsequent use;

[0045] B, ground dragon, leech, Shichangpu after drying 68 hours at 60 DEG C, cross 100 mesh sieves, mix and make medicine fine powder (I);

[0046] C. Soak Gastrodia elata, Polygonatum, and Ligustrum lucidum in water for 0.5 hours, add water to decoct 3 times, add 10 times the amount of water to decoct for 2 hours for the first time, add 8 times the amount of water to decoct for 1.5 hours for the second time, add water for the third time 8 times the amount of water to decoct for 1 hour. Each decoction was left to settle for more than 12 hours, and then filtered several times. Combine three filtrates, and the filtrate is concentrated to a relative density of 1.36 to obtain a clear paste (II);

[0047] D, get medicine fine powder (I),...

Embodiment 3

[0050] Composition: Gastrodia elata 30g, Polygonatum 60g, Earthworm 15g, Ligustrum lucidum 60g, leech 15g, Shichangpu 40g.

[0051] Preparation:

[0052] A, according to the above weight ratio, take the raw material medicine for subsequent use;

[0053] B, ground dragon, leech, Shichangpu after drying 74 hours at 60 ℃, cross 100 mesh sieves, mix and make medicine fine powder (I);

[0054] C, Gastrodia elata, sealwort, Ligustrum lucidum were soaked in water for 1 hour, decocted in water twice, filtered and combined filtrate, concentrated to a relative density of 1.40, and clear paste (II) was obtained;

[0055] D, get medicine fine powder (I), clear ointment (II) and mix, pulverize, cross 60 mesh sieves, use pan-making method or molding method to make pills, get pills after drying.

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Abstract

The invention discloses a medicine for treating vascular dementia, which is prepared by the following crude medicines according to parts by weight: 10-30 parts of gastrodia elata, 10-60 parts of sealwort, 10-60 parts of fructus ligustri lucidi, 3-15 parts of lumbricus, 1-15 parts of leech and 6-40 parts of rhizoma acori graminei. The medicine takes six crude medicines as active ingredients; and the medicine is prepared by acceptable accessories or auxiliary components on pharmacy; and the medicine can be table, capsule, pill, granules, oral liquid or mixture. The invention further discloses a preparation method of the medicine, specifically the specific preparation method for the pill. The medicine prepared by the method is capable of improving the abnormal behaviour of sufferers obviously and improving life quality; the medicine has no obvious toxic or side effects and adverse effect; and the clinical dosage is safe and reliable. The preparation method provided by the invention is advanced; the quality is steady and controllable; the content meets the standard; and the drug test index is qualified so as to ensure the safe and effective clinical medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a medicine for treating vascular dementia and a preparation method thereof. Background technique [0002] Vascular dementia is a syndrome in which brain function declines to a certain extent due to cerebrovascular disease factors such as multiple cerebral infarctions. With the aging of the population, dementia has become one of the common and frequently-occurring diseases that endanger human health. Vascular dementia is the main type of senile dementia, and its incidence is also increasing. my country's national dementia epidemiological statistics also show that with the aging of the population and changes in diet structure, the incidence of vascular dementia is on the rise. Therefore, exploring effective methods of treating and preventing vascular dementia has become an important topic in the field of geriatric medicine, and has also become a hot topic for Chinese medicine sch...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P25/28A61K35/62A61K35/64
Inventor 李智杰张义生周才新梁惟俊金海涛
Owner WUHAN HOSPITAL OF TRADITIONAL CHINESE MEDICINE