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Method for transforming danshinolic acid B into tanshinol

A technology of salvianolic acid and danshensu, which is applied in the field of danshensu preparation, can solve the problems of conversion into danshensu, and achieve the effect of increasing the content

Active Publication Date: 2012-10-03
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The technical problem to be solved by the present invention is to provide a method for converting salvianolic acid B into danshensu for the problem that salvianolic acid B cannot be converted into danshensu in the extraction, purification, and refining processes. At the end of the extract, the salvianolic acid B is completely converted into danshensu at one time, the content of salvianolic acid B in the extract is zero, and the content of the target danshensu has been greatly increased

Method used

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  • Method for transforming danshinolic acid B into tanshinol
  • Method for transforming danshinolic acid B into tanshinol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take Danshen medicinal materials, after selection, removal of impurities, and cutting, weigh 400Kg of net medicinal materials, put them into the extraction tank, add purified water 6 times the amount of medicinal materials, soak in warm (40-50°C) for 30 minutes, boil and keep warm for 2 hour, add 5 times the amount of purified water for the second time, heat it for 1 hour after boiling, filter, pass through a 100-mesh sieve, combine the filtrate, and concentrate under reduced pressure until the volume is less than 1 times the weight of the medicinal material. After 2 alcohol precipitations (the first alcohol content reaches 60%, the second alcohol content reaches 80%) and 1 water precipitation, the single-effect concentration reaches a relative density of 1.25, (detection: the content of Danshensu is 8.7mg / g, the content of salvianolic acid B is: beyond the detection range of the equipment and cannot be calculated), adjust the pH to 8-10, and sterilize: the loading capa...

Embodiment 2

[0026] Take Danshen medicinal materials, after selection, removal of impurities, and cutting, weigh 400Kg of net medicinal materials, put them into the extraction tank, add purified water 6 times the amount of medicinal materials, soak in warm (40-50°C) for 30 minutes, boil and keep warm for 2 hour, add 5 times the amount of purified water for the second time, heat it for 1 hour after boiling, filter, pass through a 100-mesh sieve, combine the filtrate, and concentrate under reduced pressure until the volume is less than 1 times the weight of the medicinal material. After 2 alcohol precipitations (the first alcohol content reaches 60%, the second alcohol content reaches 80%) and 1 water precipitation, the single-effect concentration reaches a relative density of 1.25, (detection: Danshensu content is 8.9mg / g, the content of salvianolic acid B is: beyond the detection range of the equipment and cannot be calculated), adjust the pH to 8-10, and sterilize: the loading capacity of...

Embodiment 3

[0028] Take Danshen medicinal materials, after selection, removal of impurities, and cutting, weigh 400Kg of net medicinal materials, put them into the extraction tank, add purified water 6 times the amount of medicinal materials, soak in warm (40-50°C) for 30 minutes, boil and keep warm for 2 hour, add 5 times the amount of purified water for the second time, heat it for 1 hour after boiling, filter, pass through a 100-mesh sieve, combine the filtrate, and concentrate under reduced pressure until the volume is less than 1 times the weight of the medicinal material. After 2 alcohol precipitations (the first alcohol content reaches 60%, the second alcohol content reaches 80%) and 1 water precipitation, the single-effect concentration reaches a relative density of 1.25, (detection: the content of Danshensu is 8.6mg / g, the content of salvianolic acid B is: beyond the detection range of the equipment and cannot be calculated), adjust the pH to 8-10, and sterilize: the loading capa...

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Abstract

The invention relates to tanshinol, in particular to transformation of danshinolic acid B in a red-rooted salvia root-extracted extract into tanshinol. At an extract sterilizing stage, danshinolic acid B in a red-rooted salvia root extract containing mixed components of danshinolic acid B and tanshinol is completely transformed into tanshinol at one time under a high temperature condition. The tanshinol content of a preparation prepared from the red-rooted salvia root extract which is transformed at a high temperature is kept stable before and after sterilization. Due to the adoption of a method disclosed by the invention, an extract of tanshinol is taken as a target component, a purifying process in an extracting process is reduced, and the content of target tanshinol is increased greatly. The equipment investment is small, and the method is suitable for industrial production.

Description

Technical field: [0001] The invention relates to a preparation method of danshensu, in particular to a method for completely converting salvianolic acid B in salvia miltiorrhiza extract containing salvianolic acid B and danshensu into danshensu at one time. Background technique: [0002] Chinese name: Danshensu (phenolic aromatic acid compound, brown or yellow), English name: Danshensu, alias: B-(3,4-dihydroxyphenyl) lactic acid, D(+)B-(3,4 -Dihydroxyphenyl) lactic acid Salvia A, chemical name: Propanoic acid, 3-(3,4-dihydroxyphenyl)-2-hydroxy-, molecular formula C9H10O5, molecular weight: 198.17. [0003] The structural formula is as follows: [0004] [0005] Chinese name: salvianolic acid B, English name: Lithospermic acid B, alias: salvianolic acid B, salvianolic acid B, salvianolic acid B, formed by condensation of 3 molecules of danshensu and 1 molecule of caffeic acid, with two Carboxyl group, molecular formula is C36H30O16, molecular weight: 718.61. [0006] Th...

Claims

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Application Information

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IPC IPC(8): C07C59/52C07C51/487
Inventor 叶湘武余渊冯世明
Owner GUIZHOU JINGFENG INJECTION
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