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Novel bandage including a web of microfibres or nanofibres suitable for gelling or solubilising

A microfiber, nanofiber technology, applied in medical science, drug delivery, bandages, etc., can solve problems such as unsatisfactory resolution of repositioning

Inactive Publication Date: 2015-04-01
LABORATOIRE URGO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Although many application systems have been developed over the past two decades to facilitate the application of these dressings, these systems do not satisfactorily solve the problem of repositioning; especially for painless removal of adhesive dressings immediately after first placement problem, there is currently no ideal solution

Method used

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  • Novel bandage including a web of microfibres or nanofibres suitable for gelling or solubilising
  • Novel bandage including a web of microfibres or nanofibres suitable for gelling or solubilising

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Example 1: Preparation of Standard Hydrocolloid Dressings

[0116] A hydrocolloid viscous mass was prepared consisting of the following compounds (content expressed in weight per 100 g of viscous mass):

[0117]

[0118] The hydrocolloid viscous mass is obtained by carrying out the following method:

[0119] Compounds 1, 2, 3, 8 and 9 were added to a Z-arm blender at a set temperature of 140 °C.

[0120] Compound 4 was added at 30 minutes.

[0121] Compound 7 was added at 40 minutes.

[0122] Compound 5 was added at 45 minutes.

[0123] Compound 6 was added at 60 minutes.

[0124] The mixer was emptied at 80 minutes.

[0125] The viscous hydrocolloid mass was heated to a temperature of about 110-130° C. and then coated onto a backing consisting of a 30 μm thick polyurethane film. The composite formed by the hydrocolloid substance and the backing is then cut into individual dressings, and on the free adhesive hydrocolloid surface, a protective sheet made of sili...

Embodiment 2

[0126] Embodiment 2: the preparation of dressing of the present invention

[0127] The viscous hydrocolloid mass prepared in Example 1 was heated to a temperature of about 110-130° C. and then coated onto a backing consisting of a 30 μm thick polyurethane film. The composite formed by the hydrocolloid adhesive and the polyurethane film is cut into individual dressings.

[0128] Subsequently, a mesh is deposited on the empty surface (the side not bonded to the backing) of the hydrocolloid adhesive, the mesh made of polyvinyl alcohol-based polyvinyl alcohol with a diameter of 100-200 nm (sold by Seppic as 40-88 products) of electrospun nanofibers pre-formed.

[0129] By 10-15g / m 2 The nanofiber web is simply deposited in an amount of , depositing the nanofibers in the center of the dressing.

[0130] A protective sheet made of silicon polyester is covered on the surface of the viscous hydrocolloid substance with nanofibers.

Embodiment 3

[0131] Example 3: Demonstration of the Performance of the Dressing of the Invention

[0132] The adhesive strength of the dressings prepared in Example 1 and Example 2 was measured after exposure to saline solution used to simulate wound exudate, in order to evaluate the comparison between the dressing (Example 1) containing traditional hydrocolloid adhesive material and the present invention. To illustrate the difference in the removal performance of the dressing (Example 2) comprising a hydrocolloid adhesive substance, the dressing according to the invention has a nanofibrous web on the surface that will come into contact with the skin.

[0133] For this purpose, the "probe tack" method is used; the purpose of this method is to measure the compressive stress P 0 Detachment of a cylindrical probe applied to a viscous substance at a given time t.

[0134] equipment

[0135] Specifically, using figure 1The apparatus represented in implements the method.

[0136] This device...

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Abstract

The present invention relates to a repositionable bandage including an adhesive hydrocolloid mass, wherein said bandage includes, on at least one portion of the surface of the adhesive mass intended for being in contract with the wound when the bandage is being used, a web of microfibers or nanofibers, at least 90% and preferably at least 95% of which being made up of one (or more) material(s) selected among natural or synthetic polymers, and being suitable for solubilizing or gelling in under ten seconds, and preferably still in less than one second when in contact with the exudate from the wound. The bandage according to the invention is intended for treating wounds such as blisters, exuding wounds, burns and dermal-epidermal lesions, whether superficial, deep, chronic or acute.

Description

technical field [0001] The present invention relates to novel repositionable wound dressings comprising adhesive hydrocolloid mass intended for use in the treatment of wounds, such as exudative wounds, burns, superficial or deep epidermal- Injuries to the dermis, which may be acute or chronic, the wound dressing is especially intended for the treatment of blisters. Background technique [0002] Dressings containing hydrocolloids have been known for more than 20 years. They consist of a backing on which is deposited an adhesive substance comprising hydrocolloids. As an example, mention may be made of the product sold by Laboratoires URGO under the name and a product sold by Coloplast called The product. Dressings containing an adhesive substance comprising hydrocolloids are likewise known and sold, for example under the name Urgo Traitement, sold by Laboratoires URGO, specifically for the treatment of blisters products and sold by Johnson & Johnson under the name Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/58
CPCA61L2400/12A61L15/58
Inventor 让-马克·佩尔诺
Owner LABORATOIRE URGO