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Cosmetic active ingredient-containing lipidosome as well as preparation method and application thereof

A technology for active ingredients and liposomes, which is applied to liposomes containing cosmetic active ingredients and the fields of their preparation and use, and can solve the problems of uneven particle size distribution of liposomes, high cost, and limited cosmetic applications of liposomes.

Active Publication Date: 2015-05-13
王海龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the application of liposomes in the field of cosmetics still faces some technical challenges: (1) Although there are many methods suitable for preparing liposomes in the laboratory, the preparation methods of liposomes currently applicable to industrial The high cost of requirements and equipment investment limits the application of liposome cosmetics
(2) The liposome cosmetic particle size that existing method prepares is bigger and size distribution is uneven (100-800nm), although the liposome cosmetic of common 100-200nm particle size has been called nano-liposome, but Its size range exceeds the accepted nanometer size 10-100nm
Ultrasonic dispersion is a common method for preparing small liposomes, but the particle size distribution of the prepared liposomes is uneven, and a considerable part of the liposome particle size exceeds 100nm

Method used

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  • Cosmetic active ingredient-containing lipidosome as well as preparation method and application thereof
  • Cosmetic active ingredient-containing lipidosome as well as preparation method and application thereof
  • Cosmetic active ingredient-containing lipidosome as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0098] Example 1 Preparation of nanoliposomes containing vitamin E by host-guest method (the molar ratio of guest molecule to host molecule is 1:5)

[0099] Mix 0.01 g of 1-stearoyl-2-oleoyl lecithin (chemical name 1-stearoyl-2-oleoyl-sn-glyceryl-3-phosphocholine, SOPC, molecular weight 788) and 0.6 mg of fat-soluble Vitamin E oil (VE, molecular weight 473) was dissolved in 25 ml of chloroform, put into a 100 ml round bottom flask, and the solvent was evaporated to dryness under reduced pressure. Add 25 mL of phosphate-buffered saline solution containing 2 mmol / L n-dodecyl-β-D-maltoside (nonionic surfactant) to the round bottom flask, pH 7.4. SOPC and vitamin E were completely dissolved in the nonionic surfactant phosphate buffered saline solution by shaking the round bottom flask. 0.33 g of γ-cyclodextrin (molecular weight 1297) was dissolved in 50 ml of water at room temperature (25° C.) to obtain a 5 mmol / L aqueous solution of γ-cyclodextrin. The mixed solution of SOPC an...

Embodiment 2

[0101] Example 2 Preparation of solid-state nanoliposomes containing vitamin E

[0102] Dissolve 0.32 g of 1-stearoyl-2-oleoyl lecithin (SOPC, molecular weight 788) and 10 mg of vitamin E (VE, molecular weight 473) with 50 ml of chloroform, put them in a 250 ml round bottom flask, and place under reduced pressure The solvent was evaporated to dryness. Add 100 ml of phosphate buffered saline solution containing 16 mmol / L nonyl-β-D-glucoside (non-ionic surfactant) to the round bottom flask, pH 7.4, stir and warm the solution to 55°C , so that SOPC and vitamin E are completely dissolved in the nonionic surfactant phosphate buffered saline solution. Dissolve 4 g of β-cyclodextrin in 100 ml of water at 55°C and keep warm. Mix under vigorous stirring for 15 minutes. Thus, a very small liposome with a molar ratio of SOPC: vitamin E of 100:5 was obtained. When standing to room temperature, a pale yellow cyclodextrin-nonylglucoside complex precipitated, and the precipitate was remo...

Embodiment 3

[0104] Example 3 Preparation of vitamin E-containing nanoliposomes using amphoteric surfactants

[0105] Dissolve 0.01 g of 1-stearoyl-2-oleoyl lecithin (SOPC, molecular weight 788), 3 mg of fat-soluble vitamin E oil (VE, molecular weight 473) in 25 ml of chloroform, and put them in a 100 ml round bottom flask , and evaporate the solvent to dryness under reduced pressure. Add 50 mL of 1 mmol / L to the round bottom flask LO (Lauryl Dimethylamine Oxide) (amphoteric surfactant) in Phosphate Buffered Saline, pH 7.4. The SOPC and vitamin E were completely dissolved by shaking the round bottom flask. 0.10 g of α-cyclodextrin was dissolved in 50 ml of water at room temperature. The obtained SOPC and vitamin E mixed solution was added to the α-cyclodextrin aqueous solution, and mixed for 15 minutes under vigorous stirring. Thus, a very small liposome with a molar ratio of SOPC: vitamin E of 100:5 was obtained. The particle size distribution of the ultrafine liposomes prepared in...

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Abstract

The invention relates to cosmetic active ingredient-containing lipidosome as well as a preparation method and application thereof. The cosmetic active ingredient-containing lipidosome is small and uniform in particle size, so that the wrapped active ingredients can permeate the cuticles to the deep layer of skin so as to effectively realize deep skin care. Moreover, due to the small particle size, the collision and sedimentation probability of the finished lipidosome product is decreased and the stability of the lipidosome cosmetic is improved. The cosmetic active ingredient-containing lipidosome is prepared by a host-guest chemical method, so that the lipoid molecules and the active ingredient molecules are uniformly mixed on the molecular level, so that the gathering inactivation phenomenon of the active ingredients is avoided; the preparation condition is mild, so that the active ingredients are prevented from damage.

Description

technical field [0001] The invention relates to a liposome containing cosmetic active ingredients, a preparation method and application thereof. Background technique [0002] Liposome is a supramolecular structure (spherical microcapsule) formed by the self-assembly of lipid molecules with a bimolecular layer similar to biological membranes. The layer structure and inner capsule cavity are usually tens of nanometers to tens of microns in diameter. Since its structure was confirmed in the 1960s, drug delivery systems using liposomes as carriers have been widely used. In 1986, the French company Doir developed a product named The liposome cosmetic series realizes the practical application of liposome in the field of skin care and cosmetics. Making moisturizers and vitamins into liposomes can take advantage of their slow-release characteristics to prolong the time of skin protection; making sunscreens into liposomes can increase the permeability in the skin and increase the...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61Q19/00
Inventor 王海龙
Owner 王海龙
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