Irbesartan hydrochlorothiazide capsule

A technology of hydrochlorothiazide and irbesartan, which is applied in the field of irbesartan hydrochlorothiazide capsules and capsules, and achieves the effect of small possibility, not easy to burst release, and safe to take

Inactive Publication Date: 2012-10-24
NANJING ZENKOM PHARMA
View PDF4 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its characteristics of gradually releasing a certain amount of effective drugs at different time periods within 8 hours overcome the disadvant

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Irbesartan hydrochlorothiazide capsule
  • Irbesartan hydrochlorothiazide capsule
  • Irbesartan hydrochlorothiazide capsule

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0021] Example 1

[0022]

[0023] The preparation method is as follows: take the prescription amount of irbesartan, hydrochlorothiazide, carrageenan, and mannitol and mix them uniformly, use water as a binder, granulate with 24 mesh, dry under reduced pressure at 45°C for 2 hours, and add the prescription amount The cross-linked polyvinylpyrrolidone and talc powder are mixed uniformly and filled into No. 0 capsules.

[0024] Cumulative release test results: The release of the irbesartan hydrochlorothiazide capsules prepared by the present invention is close to the 0-level release, while the commercially available irbesartan hydrochlorothiazide capsules have a significant in vivo burst release due to the secondary administration.

[0025] Time(h)

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an irbesartan hydrochlorothiazide capsule. The capsule includes the components of irbesartan, hydrochlorothiazide, carrageenan, mannitol, crosslinked polyvinylpyrrolidone and talcum powder. The irbesartan hydrochlorothiazide capsule enables medicines to slowly release step by step, the phenomenon of sudden releasing cannot occur, blood concentration is stable, medicine effect can maintain more than 8 hours, adverse reaction caused by medicine sudden releasing is avoided, and pharmacy safety is added. The irbesartan hydrochlorothiazide capsule can be used for treating primary hypertension.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, and relates to a capsule, in particular to an irbesartan-hydrochlorothiazide capsule. Background technique [0002] Hypertension is defined as elevated arterial systolic and / or diastolic blood pressure at rest. Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension points. There are many reasons for the onset of hypertension, which can be divided into two aspects: genetic and environmental. [0003] The blood pressure standard recommended by the World Health Organization (WHO) is: the systolic blood pressure of normal adults should be less than or equal to 140mmHg (18.6kPa), and the diastolic blood pressure should be less than or equal to 90mmHg (12kPa). That is, the systolic blood pres...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/52A61K31/549A61K47/36A61P9/12A61K31/4184
Inventor 祁艳徐卓业
Owner NANJING ZENKOM PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap