Application of dlk1 in the diagnosis and prognosis of liver cancer

A liver cancer prognosis and application technology, applied in the field of oncology and diagnosis, can solve the lack of serum markers and other problems
CN102778566BActive Publication Date: 2016-01-13SHANGHAI INST OF ONCOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF ONCOLOGY
Publication Date
2016-01-13

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Abstract

The invention relates to application of DLK1 in diagnosis and prognosis of a liver cancer. Specifically speaking, the invention provides application of preadipocyte factor-1 (DLK1 protein) in (a) preparation of a diagnostic reagent or kit for prognosis detection of a liver cancer and (b) preparation of a diagnostic reagent or kit for serum detection of a liver cancer. The invention also provides corresponding detection kits.
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Description

technical field

[0001] The present invention relates to the fields of oncology and diagnostics. More specifically, the present invention relates to the application of DLK1 in the diagnosis and prognosis of liver cancer. Background technique

[0002] DLK1 (Delta-like1homologue), also known as Pref-1 (preadipocyte factor-1), is a gene first discovered and cloned in neuroblastoma (LabordaJetal, JBiolChem, 1993, 268 (6): 3817-3820 ), located on human chromosome 14q32.

[0003] DLK1 protein plays a certain role in cell differentiation, especially expressed in endoderm-derived liver cells and respiratory epithelial cells. With the increase of fetal gestational age, the expression of DLK1 in normal tissues gradually decreases.

[0004] The full length of the human gene Dlk1 (GeneBank accession number BC007741) is 1557bp, the open reading frame contains 1152 nucleotides, and encodes 383 amino acid residues. DLK1 protein is a transmembrane protein, including intracellular signal p...

Claims

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