Super resolution optofluidic microscopes for 2D and 3D imaging

一种超分辨率、光流体的技术，应用在用于2D和3D成像的超分辨率光流体显微镜领域，能够解决图像分辨率限制等问题

Active Publication Date: 2012-11-21
CALIFORNIA INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, in many conventional OFMs, the image resolution is limited

Method used

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  • Super resolution optofluidic microscopes for 2D and 3D imaging
  • Super resolution optofluidic microscopes for 2D and 3D imaging
  • Super resolution optofluidic microscopes for 2D and 3D imaging

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Embodiment Construction

[0035] Embodiments of the present invention will be described below with reference to the drawings. Some embodiments include a SROFM having a body (eg, a microfluidic chip) that defines a fluidic channel and a photodetector with a two-dimensional array of photodetection elements (eg, a CMOS sensor array). A photodetector samples light data at a subpixel sampling rate, capturing a sequence of subpixel-shifted snapshot projections (frames) as the imaged subject moves through the fluid channel. A processor determines a motion vector of the object. Subsequently, the processor reconstructs a super-resolution (SR) 2D image of the object from the sub-pixel shifted frame sequence and motion vectors using a super-resolution algorithm (SR algorithm). The processor may also determine an SR three-dimensional image of the subject by combining multiple reconstructed HR images (viewpoints) from different angles of incidence using computed tomography.

[0036] Sub-pixel shifting of objects ...

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Abstract

A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.

Description

[0001] Cross References to Related Applications [0002] This paper is a non-provisional application of, and claims priority to, US Provisional Patent Application Serial No. 61 / 316,762, entitled "Super-Resolution Optofluidic Microscopy for 2D and 3D Imaging," filed March 23, 2010. The entire content of this provisional application is hereby incorporated by reference for all purposes. [0003] This nonprovisional application is related to the following co-pending and generally assigned patent application, the entire contents of which are hereby incorporated by reference for all purposes: [0004] US Patent Application Serial No. 12 / 398,050, filed March 4, 2009, and entitled "Optofluidic Microscopy Apparatus Using an Array of Photosensors." Background of the invention [0005] Embodiments of the present invention generally relate to optofluidic microscopes (OFMs) and OFM systems. More specifically, certain embodiments relate to super-resolution optofluidic microscopy (SROFM) f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/49G01N35/00G02B21/32
CPCG02B21/36H04N5/349G06T3/4053G02B21/0008H04N25/48G01N15/1484G01N15/147
Inventor 郑国安杨昌辉塞缪尔·杨李承亚
Owner CALIFORNIA INST OF TECH
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