Dehydration-resistant oral liquid and application thereof

Abstract

The invention provides a dehydration-resistant oral liquid which comprises sodium chloride, potassium chloride, potassium hydrogen phosphate, sodium citrate, sodium lactate, glucose, maltodextrin and mannitol. The invention has the following advantages: oral liquid provided by the invention can provide stable buffer capacity, which is favorable for maintaining stabilization of a pH value of cell sap; the digestible sugar maltodextrin which does not cause amplification of insulin response is added while application amount of glucose is reduced, which enables the possibility of amplification of insulin response to be reduced; drug storage stability is improved, and precipitation and deposition of crystals are reduced; vitamin B substances are added so as to allow energy of a body to be released and a mental state to be enhanced; distribution of all the components in a solid preparation reaches high level of uniformity.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an anti-dehydration oral liquid and its pharmaceutical use. Background technique [0002] There are many situations in which a subject may suffer from dehydration and related deficiencies such as loss of mineral salts. For example, exercise acts to deplete the body's fuel reserves and increase the rate of perspiration, which results in loss of water and minerals. These losses can be significant if the exercise is prolonged and especially if the ambient temperature is moderate or high. Other situations that can lead to dehydration include as, for example, the effects of enterotoxins (such as cholera typically in the third world), the effects of viruses (such as rotavirus typically in the developed world) or rest after surgery (such as when GI When rest is important) excessive temperature results, loss of nutrition, fever, excessive diarrhea and vomiting. Alternatively, the condit...

AI Technical Summary

Problems solved by technology

[0004] However, the existing drugs for the treatment of acute diarrhea dehydration, such as oral rehydration salts, contain less electrolytes and cannot fully replenish the loss of various electrolytes. Secondly, the existing drugs are usually solid preparations and contain a large amount of inorganic salts that are prone to hygroscopic and water-absorbing crystals. Such as sodium chloride and potassium chloride, which are not conducive to the storage of drugs; in addition, the administration of glucose can lead to amplified insulin response; at the same time, dehydration usually leads to weakness and lack of energy

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