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Application of chemokine-like factor derived polypeptides in inhibition of inflammatory lesions

A factor-like technology, applied in the field of preparation of anti-inflammatory drugs, can solve the problems of large side effects and ineffective curative effect

Inactive Publication Date: 2012-12-19
GUANGZHOU INST OF RESPIRATORY DISEASE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the theory of immune inflammation in the pathogenesis of idiopathic pulmonary fibrosis, the current treatment mainly uses immunosuppressants, such as glucocorticoids, cyclophosphamide and azathioprine, etc., but these drugs have large side effects and ineffective curative effects

Method used

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  • Application of chemokine-like factor derived polypeptides in inhibition of inflammatory lesions
  • Application of chemokine-like factor derived polypeptides in inhibition of inflammatory lesions
  • Application of chemokine-like factor derived polypeptides in inhibition of inflammatory lesions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0043] Materials used in the experiment:

[0044] 1. Experimental animals:

[0045] Healthy female SPF grade C57BL / 6 mice, weighing 18-20 g, aged 4-6 weeks, were purchased from Guangdong Medical Experimental Animal Center. Healthy female SPF-grade C57BL / 6 mice were free to eat, and the feeding environment was in line with the SPF experimental animal-level environmental facility standards, and the animal experiment was approved by the Animal Ethics Committee of the First Affiliated Hospital of Guangzhou Medical College.

[0046] 2. Main reagents and instruments:

[0047] 2.1 Main reagents

[0048] C27 polypeptide: provided by the Human Disease Gene Research Center of Peking University, or synthesized by the method described in the patent document CN 200410098627.1;

[0049] Bleomycin hydrochloride: Bleomycin hydrochloride (powder) 15mg / bottle, purchased from Nippon Kayaku Co., Ltd., drug production batch number: Y91450, implementation standard: imported drug registration cer...

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Abstract

The invention provides an application of chemokine-like factor derived polypeptides in inhibition of inflammatory lesions, and particularly relates to the application of the chemokine-like factor derived polypeptides in the preparation of anti-inflammatory drugs. The polypeptides comprise 1) polypeptides in an amino acid sequence as shown in SEQ ID NO:1; or 2) polypeptides derived by the 1) and provided with same biological functions with the polypeptides in the 1) by losing, inserting or replacing one or a plurality of amino acids in the polypeptides in the 1). The chemokine-like factor derived polypeptides can be particularly used for preparing interference or treating inflammatory lung injury diseases.

Description

technical field [0001] The invention provides the application of a chemokine-like factor-derived polypeptide in inhibiting inflammatory diseases, especially the application in preparing anti-inflammatory drugs, which belongs to the field of biomedicine. Background technique [0002] Pulmonary fibrosis or interstitial pneumonia is a common and intractable disease of the respiratory system, which represents a group of diffuse pulmonary parenchymal diseases characterized pathologically by diffuse inflammation of the alveolar walls (including respiratory bronchioles) and interstitial fibers changes (including acute and chronic diseases). Idiopathic pulmonary fibrosis is a common type of diffuse pulmonary parenchymal disease, accounting for about 60% of all pulmonary interstitial pneumonia and pulmonary fibrosis. According to the theory of immune inflammation in the pathogenesis of idiopathic pulmonary fibrosis, the current treatment mainly uses immunosuppressants, such as gluco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61P29/00A61P11/00A61P31/00
Inventor 谭亚夏刘蓉钟南山王应孙红曾嫱孙倩影张颖妹马大龙
Owner GUANGZHOU INST OF RESPIRATORY DISEASE
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