A method of assessing marker levels

A technology of markers and levels, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve problems such as deviation of research results, and achieve high accuracy and good reliability

Inactive Publication Date: 2016-04-06
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

However, due to the influence of various factors such as detection means and detection environment, the research results of various literatures have deviated. Therefore, in order to evaluate the level of markers more accurately, it is necessary to find new methods

Method used

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  • A method of assessing marker levels
  • A method of assessing marker levels
  • A method of assessing marker levels

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Experimental program
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Embodiment Construction

[0020] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the present invention.

[0021] combine figure 1 As shown, taking the detection of the level of biomarkers related to aseptic loosening of artificial joints as an example, a method for evaluating the level of markers of the present invention includes the following steps:

[0022] Step 1: Determine the type and quantity of the impact factors of the markers to be evaluated;

[0023] In a preferred embodiment of the present invention, in this step, biomarkers with good diagnostic value can be selected, such as interleukin-1β, tumor necrosis factor (TNF)α, interleukin-8, type I collagen N-terminal peptide (NTX), 1L-6, 1L-1, RANKL, osteocalcin, PGE2, TRAP5b, OPG, OPG / RANKL, PICP, collagenase.

[0024] Step 2: Each experimental group divides the research object into an abnormal group and a control group, and detects the mar...

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Abstract

The invention relates to an analysis on marker evaluation, in particular to a marker level evaluation method which is higher in accuracy. The marker level evaluation method includes: detecting data of impact factors of each marker in each experimental group in an abnormal control group and a control group under different research conditions, performing meta-analysis for the acquired data, comparing the heterogeneity and significance of the impact factors of each marker under different research conditions, and computing an evaluation index of the level of each marker. The marker level evaluation method is higher in reliability and accuracy and can be used for the fields of environmental monitoring, chemical analysis and the like.

Description

technical field [0001] The present invention relates to an analysis for evaluating markers, in particular to a method for evaluating marker levels with higher accuracy. Background technique [0002] Artificial joint replacement is a great progress to solve refractory joint diseases, and the number of operations is increasing year by year, but the postoperative complications eventually turn to joint revision surgery to remedy. At present, the main reason for the failure of artificial joints is aseptic loosening, so preventing joint loosening is of great significance to reduce the number of revisions and prolong the life of the prosthesis. After the artificial joint prosthesis is placed in the body, bone resorption and osteolysis around the prosthesis will cause damage to the supporting structure of the prosthesis. When the damage accumulates to a certain extent, it will lead to a decrease in the stability of the artificial joint and loosening of the prosthesis. In addition t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/00
Inventor 何涛武文黄研张晓玲汤亭亭戴尅戎
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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