Preparation method and application of middle calming tablet

A technology for making Corydalis fragrans with Anzhong tablets and vinegar, which is applied in the directions of medical preparations, pharmaceutical formulas, and plant raw materials containing active ingredients, can solve the problems of large dosage, backwardness, and many impurities in patients, and achieves the effect of reducing the dosage.

Active Publication Date: 2012-12-26
SHIJIAZHUANG DONGFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Anzhong Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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  • Preparation method and application of middle calming tablet

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Effect test

Embodiment 1

[0025] Take 180g of cassia twigs, 180g of vinegar-made corydalis, 180g of calcined oysters, 120g of cumin, 120g of amomum, 60g of galangal, and 120g of licorice. In the critical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 400W, and the extraction is performed twice. Combine the extracts for 4 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave ...

Embodiment 2

[0028] Take 180g of cinnamon sticks, 180g of vinegar-made Corydalis Corydalis, 180g of calcined oysters, 120g of fennel, 120g of amomum, 60g of galangal, and 120g of licorice. 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract ...

Embodiment 3

[0031] Take 180g of cinnamon sticks, 180g of vinegar-made Corydalis Corydalis, 180g of calcined oysters, 120g of fennel, 120g of amomum, 60g of galangal, and 120g of licorice. 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwav...

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Abstract

The invention provides a preparation method of a middle calming tablet. The middle calming tablet is prepared from 180g of cassia twig, 180g of vinegar-treated corydalis tuber, 180g of calcined oyster, 120g of common fennel, 120g of amomum fruit, 60g of Chinese ginger and 120g of liquoric root serving as bulk pharmaceuticals. The middle calming tablet is prepared through ultrafine extraction and microwave extraction, so that the convent of tetrahydropalmatine is increased greatly. The invention further provides an application of the middle calming tablet to preparation of a medicament for inhibiting cell proliferation of rat breast cancer cells SHZ-88.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Anzhong tablets. Background technique [0002] Anzhong Tablets is recorded in the standard WS3-B-0929-91 of the Ministry of Health. It is made from 180g of cassia twig, 180g of vinegar-made corydalis, 180g of calcined oyster, 120g of fennel, 120g of amomum, 60g of galangal, and 120g of licorice as raw materials. It can warm the middle and dispel cold, regulate qi and relieve pain, harmonize the stomach and stop vomiting. For epigastric pain, chronic gastritis, hyperacidity, gastric and duodenal ulcer. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Anzhong Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P35/00A61K35/56A61K35/618
Inventor 不公告发明人
Owner SHIJIAZHUANG DONGFANG PHARMA
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