Preparation technology and production method for an integrated new formulation of Wuqin wine

A production method and new dosage form technology, applied in the field of Wuqin San integrated new dosage form preparation, to achieve the effect of strong slow and controlled release performance and wide target distribution

Inactive Publication Date: 2013-01-02
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, drug plasmids, microcapsules, nanoparticles, nanospheres, nanocapsules, etc., and then mix them and put them into soft and hard capsules at the same time Combined use and preparation of an integrated new dosage form or other types of integrated new dosage forms according to the above method; 2) Research and development of "nano-drug integrated new dosage form" by using nano-carrier combination technology and the theory of integrated traditional Chinese and Western medicine. The product has target It has the characteristics of wide distribution and strong slow and controlled release performance; there is no public report in the domestic literature, and the comprehensive technical characteristics of this project have certain novelty and innovation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0058] The composition of the raw materials used to make the active ingredients is——

[0059] 9 parts of Polyporus, 15 parts of Alisma, 9 parts of Atractylodes macrocephala, 12 parts of Poria cocos, 6 parts of Guizhi.

[0060] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant ste...

Embodiment 2

[0062] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0063] The composition of the raw materials used to make the active ingredients is——

[0064] 9 parts of Polyporus, 15 parts of Alisma, 9 parts of Atractylodes macrocephala, 12 parts of Poria cocos, 6 parts of Guizhi.

[0065] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according...

Embodiment 3

[0067] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0068] The composition of the raw materials used to make the active ingredients is——

[0069] 9 parts of Polyporus, 15 parts of Alisma, 9 parts of Atractylodes macrocephala, 12 parts of Poria cocos, 6 parts of Guizhi.

[0070] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 12-72 hours. The applic...

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Abstract

The invention relates to a preparation technology and production method for an integrated new formulation of Wuqin wine. The raw material composition of the active ingredients comprises (by weight parts) Umbellate pore 9, Rhizoma Alismatis 15, Rhizoma Atractylodis Macrocephalae 9, tuckahoe 12, and cassia twig 6. Its production process includes performing supersonic gas stream crushing, alcohol and water extracting, supersonic wave crushing and extracting, decoction concentrating, supersonic spray drying, nano-grinding, high-pressure homogenization, and nanoparticles preparation. The preparation technology and production method focuses on the multi-collaborative, multi-targeted advantages of nano-carrier coupling technique, can significantly reduce production costs, significantly improve the quality of products, make drug targeting property and slow controlled release property stronger after scale production, realize inside and outside administration, and can prepare into pellicle to paste on human blood to be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Wuqin Powder, and also relates to a preparation technology of a new integrated dosage form of Wuqin Powder and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reduction ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/00A61P13/12A61P7/10A61P1/16A61P31/14A61P31/20A61P9/04A61P27/16A61P13/04A61P13/00A61P15/00A61P1/00A61P1/08A61P27/02
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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