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Antiepileptic drug, preparation method and application thereof

A drug and epilepsy technology, applied in the anti-epileptic use of Panax notoginseng saponins, and the application field in the preparation of anti-epileptic drugs, which can solve problems such as blurred vision, impaired memory, rebound after drug withdrawal, drug resistance, and dependence

Active Publication Date: 2013-01-16
SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There will be side effects such as drowsiness, fatigue, blurred vision, and memory impairment, and there will also be rebound after drug withdrawal, drug resistance, and dependence, which will adversely affect the treatment of the disease.

Method used

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  • Antiepileptic drug, preparation method and application thereof
  • Antiepileptic drug, preparation method and application thereof
  • Antiepileptic drug, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Effects of Panax notoginseng Total Saponins on Penicillin Model Rats

[0038] This example is to test the effect of Panax notoginseng saponins (PNS) on the epilepsy model animal—penicillin model rats, and the details are as follows.

[0039] 1. Animal behavior

[0040]Take 90 SD rats, weighing 100-150 g, half male and half male. Randomly divided into 6 groups according to body weight, namely model group, PNS low concentration group (54mg / kg body weight / day), PNS medium concentration group (108mg / kg body weight / day), PNS high concentration group (216mg / kg body weight / day) , carbamazepine group (36mg / kg body weight / day) and carbamazepine and PNS low-concentration combination group (36mg / kg body weight / day+54mg / kg body weight / day) after three days of continuous administration, start the experiment.

[0041] One hour after the administration on the day of the experiment, penicillin was injected intraperitoneally at 8 million U / kg, and its behavior was observ...

Embodiment 2

[0063] Example 2 Effects of Panax notoginseng Saponins on Electrically Stimulated Model Mice

[0064] This example is to test the effect of Panax notoginseng saponins (PNS) on the epilepsy model animal—electric stimulation model mouse, which is detailed as follows.

[0065] Take 150 Kunming male mice weighing 20-30g. The mice were randomly divided into 6 groups according to the degree of systemic stiffness response caused by electrical stimulation, namely the model group, the low concentration PNS group (78 mg / kg body weight / day), the medium concentration group (156 mg / kg body weight / day) ), PNS high concentration group (312mg / kg body weight / day), carbamazepine group (52mg / kg body weight / day), and carbamazepine and PNS low concentration group (52mg / kg body weight / day+78mg / kg body weight / Day) After one week of continuous administration, the experiment was started.

[0066] On the day of the experiment, electrical stimulation was performed one hour after administration un...

Embodiment 3

[0072] Example 3 Effects of Panax notoginseng Total Saponins on Rats with Acute Epilepsy

[0073] This example is to test the effect of Panax notoginseng saponins (PNS) on the epilepsy model animal—acute epilepsy model rats ignited by lithium-pilocarpine, and the details are as follows.

[0074] 1. Animal behavior

[0075] Take 108 SD rats, weighing 200-300 g, half male and half male. Randomly divided into 6 groups according to body weight, namely model group, PNS low concentration group (54mg / kg body weight / day), PNS medium concentration group (108mg / kg body weight / day), PNS high concentration group (216mg / kg body weight / day ), carbamazepine group (36mg / kg body weight / day) and carbamazepine and PNS low-concentration combination group (36mg / kg body weight / day+54mg / kg body weight / day) after three days of continuous administration, the experiment began.

[0076] 24 hours before the experiment, 3 mmol / kg (127 mg / kg) of lithium chloride was injected intraperitoneally. After...

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Abstract

The invention provides a drug for preventing or treating epilepsia. The drug is a unit dosage form containing an active component of notoginseng leaf saponins, wherein the unit dosage form is that 0.50-3 g of the notoginseng leaf saponins is contained in per unit. The invention also provides an application of the notoginseng leaf saponins in preparing the antiepileptic drug. The drug provided by the invention has significant antiepileptic curative effects, can obviously resist convulsions, reduce death rate, prolong convulsion latency and decrease attack levels, is a high-efficiency and non-toxic antiepileptic drug, and has good application prospects in preventing and treating epilepsia.

Description

technical field [0001] The present invention relates to a new application of total saponins of notoginseng leaves, in particular, the invention relates to the antiepileptic application of total saponins of notoginseng leaves and its application in the preparation of antiepileptic drugs. Background technique [0002] Sanqi (Panax notoginseng (Burk) F.H.Chen) is an Araliaceae plant, which is a traditional precious medicinal material in my country, and its dried roots are used as medicine. In recent years, studies have shown that Panax notoginseng can also be used as medicine, and its active ingredient is total saponin extract (PnGL). Aescin tablets (notoginseng saponin tablets) are traditional Chinese medicine preparations made from notoginseng saponins, and its main pharmacological effects are soothing, analgesic, lipid-lowering, anti-inflammatory and anti-tumor. At present, clinically, it is mainly used in psychiatry to replenish qi and calm the nerves, and it is less used ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P25/08
Inventor 向飞军项辉黄掌欣
Owner SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD
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