Method for treating and/or preventing inflammation and cutaneous photodamage by using water soluble extract from plant of Solanum genus and having photoprotective effect

A nightshade, water-soluble technology applied in the field of using water-soluble extracts of nightshade to treat and/or prevent inflammation and skin photodamage and photoprotection of skin, to solve problems such as inconvenience

Inactive Publication Date: 2013-01-16
G&E HERBAL BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] This shows that above-mentioned existing technology obviously still has inconvenience and defect in method, product structure and use, and urgently needs to be further improved

Method used

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  • Method for treating and/or preventing inflammation and cutaneous photodamage by using water soluble extract from plant of Solanum genus and having photoprotective effect
  • Method for treating and/or preventing inflammation and cutaneous photodamage by using water soluble extract from plant of Solanum genus and having photoprotective effect
  • Method for treating and/or preventing inflammation and cutaneous photodamage by using water soluble extract from plant of Solanum genus and having photoprotective effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] Example 1. Evaluation of in vitro anti-inflammatory effect of the water soluble extract from Solanum incanum L.

[0133] In this experiment, the applicant selected mouse macrophage RAW264.7 (mouse macrophage cell RAW264.7) with lipopolysaccharides (LPS)-induced inflammation [lipopolysaccharides (LPS)-induced inflammation] for in vitro experiments And the expression of cyclooxygenase-2 (cyclooxygenase-2, COX-2) was used as an inflammatory index to evaluate the anti-inflammatory effect (in vitro anti-inflammatory effect) of the water-soluble extract of Solanum japonica in vitro ).

[0134] experimental method:

[0135] Mouse macrophage RAW264.7 [purchased from American Type Culture Collection (ATCC), ATCC TIB-71] was seeded at a density of 1×106 cells / well containing Dubec Dulbecco's Modified Eagle's Medium (DMEM) (HyClone SH30022.01, Logan, Utah, USA) [added with 10% fetal bovine serum (FBS) (HyClone CH30160, Logan, Utah , USA), 4mM L-glutamine (L-glutamine) and 4.5g...

Embodiment 2

[0140]Embodiment 2. Evaluate of the therapeutic effects of the Solanum incanum L.solution and the Solanum incanum on the hairless mice with UV-B-induced inflammation of the eggplant solution and the eggplant gel L.gel on the hairless mouse with UV-B-induced inflammation)

[0141] experimental method:

[0142] The HRS / J hairless mice were randomly divided into 1 normal control group, 1 pathological control group and 2 experimental groups (that is, experimental groups 1 and 2) (n=4 in each group), wherein the HRS / J of the normal control group The hairless mice did not receive any treatment, while the other groups of HRS / J hairless mice were induced with inflammatory response according to the method described in item 2 "Induction of Inflammation and Photodamage" of "General Experimental Methods" above.

[0143] From the first day of UV-B irradiation, the HRS / J hairless mice of experimental group 1 were orally administered (administered orally) to prepare the water-soluble extra...

Embodiment 3

[0169] Example 3. Evaluate of the therapeutic effects of the Solanum incanum L.solution and the Solanum incanum L.solution and the Solanum incanum L.solution and the Solanum incanum L.solution and the Solanum Gel for the treatment of hairless mice with UV-B-induced photodamage incanum L.gel on the hairless mouse with UV-B-induced photodamage)

[0170] experimental method:

[0171] The HRS / J hairless mice were randomly divided into 1 normal control group, 1 pathological control group and 2 experimental groups (that is, experimental groups 1 and 2) (n=4 in each group), wherein the HRS / J of the normal control group The hairless mice did not receive any treatment, while the other groups of HRS / J hairless mice were subjected to photodamage according to the method described in item 2 "Inflammation and photodamage induction" of the above "General Experimental Methods".

[0172] From the first day of UV-B irradiation, the HRS / J hairless mice in experimental group 1 were orally admin...

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Abstract

The invention provides a method for treating and / or preventing inflammation and cutaneous photodamage by using a water soluble extract from the plant of Solanum genus and having a photoprotective effect. The water-soluble extract of the nightshade contains solasonine and solamargine.

Description

[0001] technical field [0002] The present invention relates to pharmaceutical compositions and methods for treating and / or preventing inflammation and skin photodamage, as well as cosmetic compositions with photoprotective effect, involving a plant of the genus Solanum Use of water soluble extract from plant of Solanum genus. Background technique [0003] The present invention relates to pharmaceutical compositions and methods for treating and / or preventing inflammation and skin photodamage, as well as cosmetic compositions with photoprotective effect, involving a plant of the genus Solanum Use of water soluble extract from plant of Solanum genus. [0004] In the process of aerobic organisms (aerobic organisms) using oxygen for respiration, reactive oxygen species (reactive oxygen species, ROS) and free radicals (free radicals) will be generated, while ultraviolet (ultraviolet, UV), ionizing radiation (ionizing radiation) and exposure to drugs or xenobiotics can also lea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K31/706A61K8/97A61K8/63A61P17/00A61Q17/04
Inventor 郭国华许汉铭
Owner G&E HERBAL BIOTECHNOLOGY CO LTD
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