Glimepiride dispersible tablet and preparation method thereof
A technology of glimepiride and dispersible tablets, which is applied in the field of medicine, can solve the problems of cumbersome operation, high investment, waste of raw materials, etc., and achieve the effect of simple preparation process, simplified operation process, safe and reliable quality
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Embodiment 1
[0041] Example 1 Preparation of Glimepiride Dispersible Tablets
[0042] Each 1000 glimepiride dispersible tablets (specification: 1mg) contains the following components:
[0043] Glimepiride 1g lactose 83g Crospovidone 2.5g Povidone 0.45g microcrystalline cellulose 9.55g Croscarmellose Sodium 3g Magnesium stearate 0.5g gross weight 100g
[0044] Preparation process: Glimepiride raw materials are crushed and passed through a 80-mesh sieve, lactose is passed through a 150-mesh sieve, the remaining auxiliary materials are passed through a 60-mesh sieve, and the binder povidone is prepared into a 3% aqueous solution for later use. Premix the raw materials of glimepiride, lactose, and crospovidone in the prescribed amount in a wet mixing granulator, add an aqueous binder solution, and make a soft material. 20-mesh granulation, drying at 50°C, 20-mesh granulation. Adding excipients (microcrystalline cellulose, croscarmello...
Embodiment 2
[0045] Example 2 Preparation of Glimepiride Dispersible Tablets
[0046] Each 1000 glimepiride dispersible tablets (specification: 2mg) contains the following components:
[0047] Glimepiride 2g lactose 178g Croscarmellose Sodium 4g Povidone 0.9g Low-substituted hydroxypropyl cellulose 5.1g microcrystalline cellulose 8.3g Magnesium stearate 1.7g gross weight 200g
[0048] Preparation process: Glimepiride raw materials are crushed and passed through a 100-mesh sieve, lactose is passed through a 200-mesh sieve, the remaining auxiliary materials are passed through a 60-mesh sieve, and the binder povidone is prepared into a 3% aqueous solution for later use. Premix the raw materials of glimepiride, lactose, and croscarmellose sodium in the prescribed amount in a wet mixing granulator, add an aqueous binder solution, and make a soft material. 20-mesh granulation, drying at 50°C, 20-mesh granulation. Add excipients (low-su...
Embodiment 3
[0049] Example 3 Preparation of Glimepiride Dispersible Tablets
[0050] Each 1000 glimepiride dispersible tablets (specification: 1mg) contains the following components:
[0051] Glimepiride 1g lactose 63g Low-substituted hydroxypropyl cellulose 3.25g starch 0.4g microcrystalline cellulose 3.1g sodium starch glycolate 3.5g stearic acid 0.75g gross weight 75g
[0052] Preparation process: Glimepiride raw materials are crushed and passed through a 80-mesh sieve, lactose is passed through a 150-mesh sieve, the remaining auxiliary materials are passed through a 60-mesh sieve, and the binder starch is prepared into a 6% aqueous solution for later use. Premix the raw materials of glimepiride, lactose, and low-substituted hydroxypropyl cellulose in the prescribed amount in a wet mixing granulator, add an aqueous binder solution, and make a soft material. 24-mesh granulation, drying at 50°C, 24-mesh granulation. Adding addi...
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