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Cellular array chip based on adjustable micromagnetic field

A cell array and adjustable technology, applied in the field of biomedical engineering, can solve the problems of low efficiency and long cycle of single-cell patterned chip, and achieve the effect of simplifying operation steps, improving efficiency and shortening cycle

Active Publication Date: 2013-02-20
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problems of low efficiency and long cycle of the current single-cell patterned chip, and provide a cell array chip based on an adjustable micro-magnetic field

Method used

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  • Cellular array chip based on adjustable micromagnetic field
  • Cellular array chip based on adjustable micromagnetic field
  • Cellular array chip based on adjustable micromagnetic field

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Embodiment Construction

[0022] Below in conjunction with accompanying drawing and embodiment further illustrate the present invention.

[0023] The cell array chip based on the adjustable micro-magnetic field proposed by the present invention is composed of a base layer, a ground layer, a first insulating layer, a microcoil array layer, a second insulating layer, a ferromagnetic layer, and a third insulating layer. Conductive windows are respectively etched on the first insulating layer, the second insulating layer, the ferromagnetic layer and the third insulating layer; electrode, and connected to the ground layer through the conductive window of the first insulating layer; the coil of the ferromagnetic layer corresponding to the micro-coil array layer has an array of through holes, such as figure 1 shown.

[0024] Its preparation process of above-mentioned chip is:

[0025] Step 1: Wash and dry 4-inch round Pyrex double-sided polished glass slides with bubble washing solution;

[0026] Step 2: U...

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Abstract

The invention discloses a cellular array chip based on adjustable micromagnetic field, belonging to the technical field of biomedical engineering. The chip is formed by sequentially laminating a substrate layer, a grounding layer, a first insulating layer, a microcoil array layer, a second insulating layer, a ferromagnet layer and a third insulating layer, wherein a conducting window is respectively etched on the first insulating layer, second insulating layer, ferromagnet layer and third insulating layer; the microcoil array layer is composed of a microcoil array and a positive pole bonding pad; and the ferromagnet layer is provided with a through hole array corresponding to microcoils on the microcoil array layer. In the chip disclosed by the invention, the patterned microcoil array is utilized to form a gradient magnetic field and some columns of intangible magnetic particle cages; and when the magnetic particles are attracted to the center, the magnetic particles entering the inside of the magnetic field can not depart from the restriction of the magnetic field if not having sufficient power, thereby enhancing the cell patterning efficiency, shortening the cell patterning period and simplifying the unicell patterning operation steps.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to a cell array chip based on an adjustable micro-magnetic field. Background technique [0002] The data obtained in most traditional biological experiments are the statistical average results of a large number of cells. However, due to the different ion channel states, the dynamic performance of the cytoskeleton, and the differences in the internal network of cells, cells have individual differences. Traditional biological experiments often ignore the rich information carried by the differences of individual cells. Relevant studies have shown that the strong adaptability and drug resistance of cancer cells come from the individual differences of cancer cells. Therefore, targeted research on heterogeneous cells is very important for exploring the mechanism of cancer cells and developing anticancer drugs. Single-cell array is an important method and way t...

Claims

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Application Information

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IPC IPC(8): C40B40/02
Inventor 任大海尤政王俊谢锦宇
Owner TSINGHUA UNIV
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