A
system and method for sequencing a molecule, where the
system includes: a
nanopore sensor
chip (602) with an array (200) of cells, where each
cell of the array of cells has a
working electrode (202) and a switch (406). The
system also has a flow channel configured to flow an
analyte comprising the molecule across the array of cells; a counter
electrode (210) configured to apply a
voltage to the
analyte; an
alternating current voltage source (228) configured to apply an AC
voltage to the
working electrode (202); a storage device (612) configured to represent either an open state or a
closed state for the switch (406); an analog-to-
digital converter (410); and one or more processors (430). The one or more processors (430) are programmed to: (1) analyze output data from the analog-to-
digital converter (410) to detect a first sub-set of cells, where each
cell of the first sub-set cells comprises a membrane with a
nanopore embedded therein; (2) analyze further output data from the analog-to-
digital converter (410) for the first sub-set of cells to detect a second sub-set of cells, where the first sub-set of cells comprises the second sub-set of cells; and in response to this analysis of the further output data: (3) update the state of the storage device (612) of each
cell of the second sub-set of cells to an open state, thereby opening the switch (406) of each cell of the second sub-set of cells so as to disconnect the
working electrode (202) of each cell of the second sub-set of cells from the AC
voltage source (228) for a period of time during a single AC modulation period.