Terbutaline sulfate oral instant film and preparation method thereof

A technology of terbutaline sulfate and oral instant film, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve problems such as difficult swallowing, complicated operation, and inconvenient carrying , to achieve the effect of good palatability, pleasant taste and quick effect

Inactive Publication Date: 2016-01-20
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is not only to provide a kind of terbutaline sulfate oral fast-dissolving film agent with good palatability, rapid disintegration when meeting saliva in the oral cavity, and fast onset of action, providing children, elderly, bedridden and severely disabled patients with A new medication option; also provide a small size, no need for water to take, easy to take and carry terbutaline sulfate oral instant film, overcome the common marketed dosage forms that are difficult to swallow, difficult to quantify, inconvenient to carry, complicated to operate, etc. problems

Method used

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  • Terbutaline sulfate oral instant film and preparation method thereof
  • Terbutaline sulfate oral instant film and preparation method thereof
  • Terbutaline sulfate oral instant film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Each tablet of terbutaline sulfate oral instant film contains 2.5 mg of terbutaline sulfate, and the composition of every 1000 tablets of film is:

[0026]

[0027]

[0028] Specific operation process: Weigh terbutaline sulfate, aspartame, microcrystalline cellulose, mannitol, titanium dioxide, disperse with 30% glycerin solution, add 0.3% pigment solution, 2% hypromellose Solution, stir while adding, after stirring evenly, degassing, the above-mentioned terbutaline sulfate suspension glue liquid is evenly coated on the flat plate, dry, cut (2cm * 2cm), obtain the terbutaline sulfate oral cavity Instant film.

[0029] The film is pink in color, has good flexibility, melts and disperses quickly in the mouth, has a good taste and sweet taste, and the melting time is 25s.

Embodiment 2

[0031] Each tablet of terbutaline sulfate oral instant film contains 2.5 mg of terbutaline sulfate, and the composition of every 1000 tablets of film is:

[0032]

[0033] Specific operation process: Weigh terbutaline sulfate, aspartame, pregelatinized starch, trehalose, titanium dioxide, disperse with 30% glycerin solution, add 0.3% pigment solution, 1% sodium alginate solution, add While stirring, after stirring evenly, degassing, the above-mentioned terbutaline sulfate suspension glue is evenly coated on the flat plate, dried, cut (2cm * 2cm), obtains the terbutaline sulfate oral cavity instant film.

[0034] The film has good flexibility, melts and disperses quickly at the entrance, has a good taste and sweet taste, and the melting time is 15-20 seconds.

Embodiment 3

[0036] Each tablet of terbutaline sulfate oral instant film contains 2.5 mg of terbutaline sulfate, and the composition of every 1000 tablets of film is:

[0037]

[0038]Specific operation process: weigh terbutaline sulfate, aspartame, low-substituted hydroxypropyl cellulose, maltitol, titanium dioxide, disperse with 30% glycerin solution, add 0.3% pigment solution, 0.3% xanthan gum solution , stirring while adding, after stirring evenly, degassing, the above-mentioned terbutaline sulfate suspension glue liquid is evenly coated on the flat plate, dry, cut (2cm * 2cm), obtain the terbutaline sulfate oral cavity instant membrane.

[0039] The film has good toughness, melts and disperses quickly at the entrance, has a good taste and sweet taste, and the melting time is 15-20 seconds.

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PUM

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Abstract

The invention discloses a terbutaline sulfate oral instant film and a preparation method thereof, and belongs to the technical field of medicines. The terbutaline sulfate oral instant film comprises active ingredients, such as terbutaline sulfate, film-forming materials, disintegrating agents and opacifying agent with effective dosages, and necessary pharmaceutically acceptable filling agents, sweetening agents and wetting agents; and coloring agents are added according to requirements. The terbutaline sulfate oral instant film is good in palatability, fast in response, small in size, and suitable for children, elders, completely-bedridden persons and patients with severe disability; the film can be rapidly dissolved in a disintegrating mode in the oral cavity; water is not needed to orally take; and people can take the medicines any time under a condition that water is inconvenient to drink.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an oral instant film containing terbutaline sulfate and a preparation method thereof. Once it comes into contact with oral saliva, it dissolves or disintegrates quickly, has a quick effect, and has the characteristics of being easy to take and carry, and does not need to be taken with water. It can relax bronchial smooth muscle, inhibit the release of endogenous spasm-causing substances and edema caused by endogenous media; enhance the fiber movement of bronchial mucosal epithelial cells, accelerate the elimination of mucus, and relax bronchi; effectively used for bronchial asthma, chronic asthmatic bronchial Inflammation, obstructive emphysema and other lung diseases with bronchospasm. Background technique [0002] With the continuous improvement of people's living standards, people's awareness of health care has gradually increased, and they have begun to pay more at...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/137A61K31/205A61K47/38A61K47/36A61K47/32A61P11/08A61P11/06A61P11/00
Inventor 赵伟卢欣李化淋
Owner 天津市聚星康华医药科技有限公司
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