Panax notoginseng polysaccharide extract and preparation method, preparations and applications thereof

A technology of Panax notoginseng polysaccharides and extracts, which can be applied in directions such as drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as unfavorable comprehensive utilization of Panax notoginseng resources, waste of Panax notoginseng resources, etc., and achieve the effects of reducing costs and improving economic benefits.

Inactive Publication Date: 2013-03-13
YUNNAN YUNKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In fact, these waste residues also contain more active substances except Panax notoginseng saponins, which are treated as waste residues, causing a considerable waste of Panax notoginseng resources, which is not conducive to the comprehensive utilization of Panax notoginseng resources

Method used

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  • Panax notoginseng polysaccharide extract and preparation method, preparations and applications thereof
  • Panax notoginseng polysaccharide extract and preparation method, preparations and applications thereof
  • Panax notoginseng polysaccharide extract and preparation method, preparations and applications thereof

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preparation example Construction

[0023] The preparation method of the Panax notoginseng polysaccharide extract of the present invention comprises the steps of extraction, concentration, refining, drying, pulverization, and inspection, specifically comprising:

[0024] The extraction is to put the waste residue after extracting the total saponins of Panax notoginseng into the extraction tank, add purified water with a volume ratio of 8~24 times, extract at a temperature of 50~60°C for 4~8 hours, and circulate leaching for 2~6 times. Filter and combine the filtrate for subsequent use;

[0025] Concentration is to concentrate the filtrate after secondary extraction to an extract with a relative density of 1.16~1.24 at a pressure of ≤0.8MPa, a temperature of ≤90°C, and a concentrated steam pressure of ≤0.3MPa;

[0026] Refining is to let the extract stand for 8~24 hours, add ethanol with a volume ratio of 3~8 times to precipitate for 8~24 hours, filter to separate the crude polysaccharide from the mother liquor, ...

Embodiment 1

[0038] Take 750 kg of Panax notoginseng, wash it, dry it until the moisture content is 10%, and crush it to a coarse powder with a particle size of 6×6~9×9mm for later use; put the coarse powder into an extraction tank, and add 60 % ethanol was leached at a temperature of 50°C for 12 hours, circulated for 5 times, filtered through a 100-mesh stainless steel screen, and the combined filtrate was used for the production of Panax notoginseng saponins, and the residue was combined for later use.

Embodiment 2

[0040] Take 750 kg of Panax notoginseng, wash it, dry it until the moisture content is 20%, and crush it to a coarse powder with a particle size of 8×8mm for later use; put the coarse powder into an extraction tank, add 90% ethanol with a volume ratio of 14 times Extract at 60°C for 8 hours, circulate leaching 3 times, filter through a 100-mesh stainless steel screen, combine the filtrates for the production of Panax notoginseng saponins, and combine the residues for later use.

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Abstract

The invention discloses a panax notoginseng polysaccharide extract and a preparation method, preparations and applications thereof. The panax notoginseng polysaccharide extract is prepared by taking waste residues produced after panax notoginseng saponins are extracted as raw materials through the steps of extraction, concentration, purification, drying, crushing and detection, wherein the content of panax notoginseng polysaccharides is not less than 15%. The preparation method of the panax notoginseng polysaccharide extract comprises the steps of extraction, concentration, purification, drying, crushing and detection, and specifically comprises the steps of adding waste residues produced after panax notoginseng saponins are extracted into purified water for extracting, carrying out filtration and concentration on the obtained object, adding ethanol into the obtained object for precipitating, and carrying out filtration, purification and drying on the obtained product so as to obtain a target dried product. Pharmaceutical excipients are added into the panax notoginseng polysaccharide extract to be prepared into powder, capsules, granules, tablets or pills; and the panax notoginseng polysaccharide extract is applied to the preparation of antineoplastic drugs and immunity enhancing drugs. According to the invention, waste residues produced after panax notoginseng saponins are extracted are reused, thereby changing waste material into things of value, facilitating the comprehensive utilization of panax notoginseng resources, reducing the cost and improving the economic benefits.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation and application, and in particular relates to a notoginseng polysaccharide extract, a preparation method, preparation and application thereof. Background technique [0002] The traditional Chinese medicine Panax notoginseng is the dried root of Panax notoginseng (Burk.) F H.Chen, an Araliaceae plant. It is mainly produced in Yunnan, Guangxi and other places, wild or cultivated. It is sweet, slightly bitter, and warm in nature. It mainly enters the liver, stomach, and large intestine meridian. It has the functions of nourishing, strengthening, nourishing blood, reducing swelling and analgesia, stopping bleeding, and enhancing immunity. At the end of the 20th century, domestic and foreign scholars conducted extensive pharmacological research and clinical experiments on Panax notoginseng, and achieved a large number of new results, which expanded the medical application field of Panax no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P35/00A61P37/04
Inventor 陈彤赵洪
Owner YUNNAN YUNKE PHARMA
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