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Use of fisetin for preparing medicaments for treatment of depression.

A technology of fisetin and depression, which is applied in the field of fisetin, can solve the problem that the possible mechanism of fisetin's antidepressant effect is not clear, and achieve a good antidepressant effect

Inactive Publication Date: 2013-03-20
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antidepressant effect of fisetin and its possible mechanism are still unclear

Method used

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  • Use of fisetin for preparing medicaments for treatment of depression.
  • Use of fisetin for preparing medicaments for treatment of depression.
  • Use of fisetin for preparing medicaments for treatment of depression.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: Mouse tail suspension test, forced swimming test, autonomous activity test, PCPA test, reserpine test

[0008] 1. Test drugs

[0009] Name: Fisetin

[0010] Properties: yellow powder, extracts from plants such as wood

[0011] Source: purchased from Shaanxi Senfu Biotechnology Co., Ltd., with a purity of 98%

[0012] Drug preparation: Dissolve fisetin in double distilled water, and prepare three doses of 5mg / kg, 10mg / kg, and 20mg / kg respectively, and give mice a dose of 0.1ml / 10g orally

[0013] 2. Control drug

[0014] Imipramine hydrochloride (imipramine hydrochloride), fluoxetine (fluoxetine hydrochloride), PCPA (p-chlorophenylalanine HCl): purchased from Sigma, USA. Before use, imipramine and fluoxetine were prepared with double-distilled water to a concentration of 10 mg / kg, and PCPA was prepared with double-distilled water to a concentration of 300 mg / kg, and intraperitoneal injection was given to mice according to the above specifications. Reserpi...

Embodiment 2

[0044] Embodiment 2: Determination of mouse monoamine oxidase, monoamine transmitter and its metabolite content

[0045] 1. Test drug: same as Example 1

[0046]2. Positive control drugs: dihydrobromokynurenamide, 4-hydroquinoline, selegiline, chlorogiline, 5-hydroxytryptamine (5-HT), norepinephrine (NA), dopamine (DA), 5- Hydroxyisobutyric acid (5-HIAA) and dihydroxyphenylbutyric acid (DOPAC) were purchased from Sigma, USA. Moclobemide was purchased from China Institute for the Control of Pharmaceutical and Biological Products.

[0047] 3. Experimental method

[0048] ① Determination of monoamine transmitters and their metabolites:

[0049] 60min after administration (fisetin, p.o.; imipramine, i.p.), the mice were quickly decapitated and sacrificed, and the frontal cortex, hippocampus, striatum and hypothalamus were quickly separated on ice, weighed and placed in Eppendorf tubes were stored in a -80°C freezer. Add 200μl ice 0.4mol / L HCLO4 to every 100mg of brain tissue,...

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Abstract

The present invention belongs to the technical field of medicine, and relates to a new application of fisetin. animal experiments show that fisetin has good anti-depressant effect, and is a relatively promising natural anti-depressant pharmaceutical drug that can be used for preparing medicaments for the treatment of depression.

Description

technical field [0001] The invention relates to a new application of fisetin, in particular to the application of fisetin in the preparation of medicaments for treating depression. Background technique [0002] Depression is a common psychiatric disease, and currently the patients suffering from depression account for 21% of the total population in the world. According to the latest data from the World Health Organization (WHO), by 2020, depression will become the second leading cause of disability. The current main drug therapy includes tricyclic drugs (TCAs), selective serotonin inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). Antidepressant effects are exerted by increasing levels of monoamine transmitters such as serotonin / norepinephrine. However, most drugs have side effects and their mechanism of action is unclear. Therefore, it is very critical to find new, efficient and safe therapeutic drugs. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P25/24
Inventor 徐英潘建春
Owner WENZHOU MEDICAL UNIV