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Application of indol-3-carbinol in preparation of medicine for treating experimental pulmonary fibrosis

An experimental technology for pulmonary fibrosis, applied in the field of medicine, to achieve the effect of improving total antioxidant capacity (T-AOC), reducing lung coefficient, and reducing the degree of pulmonary fibrosis

Inactive Publication Date: 2013-04-10
苏州中药研究所有限公司
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  • Abstract
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Problems solved by technology

The effect of I3C on bleomycin-induced pulmonary fibrosis has not been reported so far

Method used

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  • Application of indol-3-carbinol in preparation of medicine for treating experimental pulmonary fibrosis
  • Application of indol-3-carbinol in preparation of medicine for treating experimental pulmonary fibrosis
  • Application of indol-3-carbinol in preparation of medicine for treating experimental pulmonary fibrosis

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Embodiment Construction

[0024] The above solution will be further described below in conjunction with specific embodiments. It should be understood that these examples are used to illustrate the present invention and not to limit the scope of the present invention. The implementation conditions used in the examples can be further adjusted according to the conditions of specific manufacturers, and the implementation conditions not indicated are usually the conditions in routine experiments.

[0025] 1. Materials

[0026] 1. Experimental animals

[0027] SD rats, male, weighing 200±20 g, clean grade, provided by Shanghai Slack Experimental Animal Co., Ltd., license number: scxk (Shanghai) 2009-005. The experimental animals were kept in a clean animal observation room, fed adaptively for 3 days, and had free access to water and food during the administration period.

[0028] 2. Drugs and reagents

[0029] Indole-3-carbinol (Indole-3-carbinol, I3C, alias: 3-Indolemethanol, structural formula: ), mol...

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Abstract

The invention discloses an application of indol-3-carbinol in preparation of a medicine for treating experimental pulmonary fibrosis. Mouse and rat pulmonary fibrosis animal models are copied by intratracheally instilling bleomycin (BLM); indol-3-carbinol is selected as a treating medicine; the influence of indol-3-carbinol on related biochemical indexes and pathological alteration of pulmonary fibrosis animal lung tissue and serum is searched; and the prevention and treating effects on the pulmonary fibrosis animal models by indol-3-carbinol are observed, so that the experimental basis is provided for preventing the pulmonary fibrosis by indol-3-carbinol.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an application of indole-3-carbinol in the preparation of drugs for preventing and treating experimental pulmonary fibrosis. Background technique [0002] Pulmonary (interstitial) fibrosis (pulmonary fibrosis, PF) is a diffuse alveolitis and alveolar structure disorder of unknown cause, which leads to alveolar and pulmonary interstitial fibrosis, and eventually respiratory failure. It is also caused by a variety of reasons The common outcome of acute and chronic lung diseases is a pulmonary obstructive disease that seriously endangers human health. Inflammation and oxidative stress play an important role in the pathogenesis of pulmonary fibrosis. The clinical research on pulmonary fibrosis mainly focuses on idiopathic pulmonary fibrosis (IPF), which is characterized by abnormal injury of alveolar epithelial cells, fibroblast proliferation and extracellular matrix remodeling. The...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P11/00
Inventor 顾振纶蒋小岗毛新妍秦正红
Owner 苏州中药研究所有限公司
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