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Pregnancy healing oral liquid for treating abortion and preparation method of oral liquid

A technology of Yunkang oral liquid and liquid medicine, which is applied in the field of traditional Chinese medicine, can solve problems such as poor operability and repeatability, affecting the clarity of the extract, and low retention rate, so as to reduce production costs and cycles, expand clinical adaptation population, and improve Effects on Quality and Stability

Active Publication Date: 2013-05-01
回音必集团浙江齐齐制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prepared recipe adopts a simple water decoction method, which ignores the differences in the chemical components of the Chinese herbal medicines, reduces the extraction rate of active ingredients, and brings inconvenience to filtration and refining, and the decoction is prone to mildew Change
[0006] (2) Use 70% ethanol precipitation to remove impurities in the extract. This method has a low retention rate of active ingredients such as flavonoids, polysaccharides, saponins, and alkaloids, and the loss is large, and it is easy to remove some active ingredients (polysaccharides) in the prescription. Removal; the factors affecting alcohol precipitation are complicated, and the operability and repeatability are poor; the incomplete removal of impurities will affect the clarity of the extract, and affect the stability and efficacy of the preparation; this method consumes a lot of alcohol, which makes the preparation Cost increase
Calculated according to the daily prescription volume, the dose of this preparation is small, and the effective therapeutic dose cannot be reached, and the clinical efficacy may be unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: by the consumption of each crude drug: 125 parts of Chinese yam, 75 parts of Dipsacus, 100 parts of Radix Astragali, 75 parts of Angelica sinensis, 100 parts of dog ridge, 75 parts of Cuscuta, 50 parts of Sangjisheng, 75 parts of Eucommia, psoraleae 75 parts, Codonopsis 75 parts, Poria cocos 100 parts, Atractylodes macrocephala 75 parts, Ejiao 25 ​​parts, Rehmannia glutinosa 100 parts, Cornus officinalis 75 parts, Lycium barbarum 100 parts, Black plum 50 parts, Paeoniae Alba 75 parts, Amomum 50 parts, Yizhi 50 parts , 75 parts of ramie root, 50 parts of Scutellaria baicalensis, 8.3 parts of mugwort leaves.

[0037] (1) Take the prescribed amount of yam, astragalus, angelica, psoralen, codonopsis, scutellaria baicalensis, white peony root, dogwood, and medlar, soak in warm water at 50-60°C for 3-6 hours, filter, and the filtrate is set aside, and the filter residue is added with 6- Decoct with 10 times the amount of water for 1-3 hours to obtain medicinal l...

Embodiment 2

[0043] The dosage of each raw material medicine is: 130 parts of yam, 80 parts of Dipsacus, 105 parts of Astragalus, 80 parts of Angelica, 105 parts of dog spine, 80 parts of Cuscuta, 55 parts of Sangjisheng, 80 parts of Eucommia, 80 parts of psoralen, Codonopsis pilosula 80 parts, 100 parts of Poria cocos, 80 parts of Atractylodes macrocephala, 30 parts of donkey-hide gelatin, 100 parts of rehmannia glutinosa, 80 parts of dogwood, 100 parts of medlar, 55 parts of black plum, 80 parts of white peony root, 55 parts of amomum, 55 parts of Yizhi, 80 parts of ramie root 60 parts of Scutellaria baicalensis, 10 parts of Artemisia argyi

[0044] (1) According to the weight ratio of the prescription, take 6 flavors of angelica, dodder, dogwood, amomum, yizhi, and mugwort leaves and grind them into coarse powder, add 6 times the amount of water to infiltrate, and use steam distillation to collect 1000 parts of distillate and Medicinal residues, the distillate is refrigerated at 4°C-6°C...

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PUM

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Abstract

The invention discloses a preparation technology of a pregnancy healing oral liquid. On the basis that the advantages of the original technology are reserved, the improved technology adopts fractionation first and then combined decoction. A preparation method particularly comprises the following steps that volatile oil in angelica sinensis, cuscuta chinensis, fructus corni, fructus amomi, alpinia oxyphylla and folium artemisiae argyi is extracted with a steam distillation method; and medicine dregs and the rest 16 medicines (except donkey-hide gelatin) are decocted with the traditional method. According to the preparation technology, a ZTC1+1 natural clarifying agent replaces alcohol to remove unstable constituents and impurities in a water decocted liquid; the advantages of the original method are carried on; effective constituents of a whole prescription are reserved; the quality and the stability of the medicines are improved; the production cost is lowered; a production cycle is shortened; treatment effects of the medicines are ensured; and a cure rate of the medicines is increased. Steviosin serves as a sweetening agent for replacing cane sugar and honey; clinic adaptation population of the oral liquid is enlarged; and the oral liquid can reduce incidence of gestational diabetes effectively, and makes contributions to health of a mother and an infant.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. The invention relates to a Yunkang oral liquid for treating miscarriage and a preparation method thereof, in particular to an improvement of an extraction and purification process in a preparation method of Yunkang oral liquid for treating threatened miscarriage and habitual miscarriage. Background technique [0002] Threatened miscarriage and habitual miscarriage are common and dangerous diseases in gynecology. The main clinical manifestations are abdominal pain, a small amount of vaginal bleeding, lower abdominal pain, and may even cause embryonic death and maternal complications. In recent years, due to various reasons, the incidence of threatened abortion and habitual abortion among pregnant women has been on the rise. According to statistics, the incidence has reached 12%, which not only seriously threatens the health and life safety of the fetus and mother, but also Bring great m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/08A61P15/06A61K35/36
Inventor 王大冲杨楼峰郭廷富罗招丰
Owner 回音必集团浙江齐齐制药有限公司
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