Genetic recombinant human-like collagen

A technology of human collagen and human collagen, applied in the field of genetic engineering, can solve the problems of impurity removal of impurity proteins and partially degraded proteins, insufficient purity, and inability to meet higher requirements for purity.
CN103102407BActive Publication Date: 2014-04-30JIANGSU TRAUTEC MEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU TRAUTEC MEDICAL TECH CO LTD
Publication Date
2014-04-30

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Abstract

The invention discloses humanized genetic recombinant human-like collagen produced by eukaryotic bacteria. The humanized genetic recombinant human-like collagen has amino acid with the total length of 474, and is formed by connecting two sections of completely-identical human III-type collagen sections in series; the end C is connected with six histidine residue groups serving as specificity affinity purification markers. The performance of the genetic recombination human-like collagen is superior to animal collagens and original nuclear engineering bacteria recombinant collagens; and with the specificity affinity purification markers, the high-purity product is easily acquired.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a recombinant collagen and a production method thereof. Background technique

[0002] Collagen is a biopolymer substance that maintains the shape and structure of skin and tissues and organs, and is also an important substance for repairing various damaged tissues. It mainly exists in the skin, bone, cartilage, teeth, tendons, ligaments and blood vessels of humans and animals. It is an important structural protein in connective tissue and plays the role of supporting organs and protecting the body. Collagen plays an important role in maintaining the normal physiological functions of cells, tissues and organs and repairing damage. Collagen can give the necessary nutrients to the skin layer containing collagen, strengthen the activity of collagen in the skin, maintain the moisture of the stratum corneum and the integrity of the fiber structure, improve the ...

Claims

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