Chitosan-fullerene compound and preparation method

A fullerene composite and chitosan technology, applied in the field of fullerene materials, can solve the problems of single fullerene material performance, lack of moisturizing and antioxidant activity, etc., and achieve excellent physiological activity, good moisture absorption, The effect of good stability

Active Publication Date: 2013-05-15
SHENZHEN BEAUTYSTAR CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a chitosan-fullerene composite and a preparation method thereof, aiming at solving the problem that the existing fullerene materials have single properties and do not have both moisturizing and anti-oxidation properties. activity problem

Method used

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  • Chitosan-fullerene compound and preparation method
  • Chitosan-fullerene compound and preparation method
  • Chitosan-fullerene compound and preparation method

Examples

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Effect test

Embodiment 1

[0044] 5g carboxymethyl chitosan and 20mgC 60 After the fullerenes are mixed evenly, they are transferred to a ball mill. Set the temperature of the ball mill to 15°C, set the ball mill to the intermittent mode, and start and stop the ball mill 10 times: every time it runs for 10 minutes, it stops for 20 minutes. After fully mixing evenly, move the fully mixed powder into a blender, add 250ml of water, and stir thoroughly for 4 hours. A filter membrane with a pore size of 1 um was selected, and the insoluble matter was removed by suction filtration under reduced pressure to obtain a clear solution, which was a carboxymethyl chitosan-fullerene complex solution. When the carboxymethyl chitosan-fullerene complex solution is concentrated to 1 / 3 of the original volume, it is placed in a freeze dryer to remove water, and the carboxymethyl chitosan-fullerene complex can be obtained solid. Because there is basically no insoluble matter in the filtration process, the mass percentage...

Embodiment 2

[0046] 5g carboxymethyl chitosan and 100mg C 60 After the fullerenes are mixed evenly, they are transferred to a ball mill. Set the temperature of the ball mill to 15°C, set the ball mill to intermittent mode, and start and stop the ball mill 20 times: every time it runs for 10 minutes, it stops for 20 minutes. After fully mixing evenly, move the fully mixed powder into a blender, add 250ml of water, and stir thoroughly for 8 hours. Select a filter membrane with a pore size of 1 um, remove the insoluble matter by suction filtration under reduced pressure, and obtain a clear solution that is the carboxymethyl chitosan-fullerene complex solution. The carboxymethyl chitosan-fullerene complex solution When it is concentrated to 1 / 3 of the original volume, it is placed in a freeze dryer to remove water, and the carboxymethyl chitosan-fullerene complex solid can be obtained. During the preparation process, the insoluble matter obtained by filtration is fullerene solid, which weigh...

Embodiment 3

[0048] 5g carboxymethyl chitosan with 250mg C 60 After the fullerenes are mixed evenly, they are transferred to a ball mill. Set the temperature of the ball mill to 15°C, set the ball mill to the intermittent mode, and start and stop the ball mill 20 times: every time it runs for 20 minutes, it stops for 40 minutes. After fully mixing evenly, move the mixed powder to a blender, add 250ml of water, and stir thoroughly for 8 hours. A filter membrane with a pore size of 1 um was selected, and the insoluble matter was removed by vacuum filtration to obtain a clear solution, which was the carboxymethyl chitosan-fullerene complex solution. When the carboxymethyl chitosan-fullerene complex solution is concentrated to 1 / 3 of the original volume, it is placed in a freeze dryer to remove water, and the carboxymethyl chitosan-fullerene complex can be obtained solid. The insoluble matter obtained by filtration is fullerene solid, which weighs about 50 mg after drying. Therefore, in the...

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Abstract

The invention discloses a chitosan-fullerene compound and a preparation method, wherein the preparation method comprises the following steps: uniformly mixing the fullerene powder and water-soluble chitosan powder, wherein the mass ratio of fullerene powder to water-soluble chitosan is 1:250-1:20; performing ball milling on the uniformly mixed powder in a bowl mill, wherein the ball milling temperature is kept at 15-20 DEG C; dissolving the fully mixed powder after ball milling in a proper amount of water, fully stirring; filtering the stirred solution to remove the insoluble substances to obtain a chitosan-fullerene compound solution; concentrating and drying the obtained chitosan-fullerene compound solution to obtain the chitosan-fullerene compound solid. The prepared chitosan-fullerene compound has good functions of moisture absorption, moisture retention, conditioning, bacteriostasis and the like, excellent biological activity can be guaranteed, good stability is provided, and the moisture retention and antioxidation activity performance can be provided.

Description

technical field [0001] The invention relates to the field of fullerene materials, in particular to a chitosan-fullerene composite and a preparation method thereof. Background technique [0002] In the prior art, there are two main methods to solve this problem: 1) chemical modification method, that is, using chemical reaction to modify the hydroxyl or carboxyl group outside the fullerene carbon cage; 2) water-soluble polymer coating method, that is, using Water-soluble molecules such as polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and cyclodextrin wrap fullerene molecules to form a water-soluble complex). [0003] However, the above two methods only improve the solubility of fullerene in water, alcohol and ester solvents and certain biocompatibility, but in terms of performance, they are relatively simple, and they still have the function of removing free radicals and anti-oxidation. , generally do not have properties such as moisturizing, so the existing fulleren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08K5/01
Inventor 李慧陈寿王春儒居学成
Owner SHENZHEN BEAUTYSTAR CO LTD
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