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Pepromia pellucida B composition used for inhibiting angiogenesis and preparation method

A technology of herbalin and composition, applied in the field of herbalin B composition, can solve problems such as preparations containing herbalin B that are not reported, achieve prevention and control of tumor cell metastasis, huge economic and social benefits, operation simple effect

Inactive Publication Date: 2015-06-10
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is no report in the art that contains the preparation of orthoperine B

Method used

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  • Pepromia pellucida B composition used for inhibiting angiogenesis and preparation method

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preparation example Construction

[0024] Preparation of Herba-Peterin B:

[0025] Use 16 times the amount of water to extract 1Kg of Echinacea 3 times, 1 hour each time, combine the extracts, filter under reduced pressure once, combine the extracts, the specific gravity of the water extract is 1.005, and load the sample at a flow rate of 1BV / h To the DM130 macroporous resin column, the volume ratio of the amount of macroporous resin to the water extract of boronine B is 1:25. Sequentially eluted with 8BV of distilled water, 50% ethanol, 70% ethanol and 95% ethanol, collected in fractions, concentrated and dried the 70% ethanol part under the conditions of -0.1MPa and 70°C, and obtained the crude boronine B with a purity of 41%, weighing 3.2g.

[0026] Dissolve 3.2g of the crude properine B in ethanol containing about 10% water, mix the sample with silica gel, and load the sample by dry method, wherein the amount of silica gel is 320g, the diameter-to-length ratio of the silica gel column is 1: 8, and the volu...

Embodiment 1

[0028] Preparation of Herbaperine B Solid Dispersion: Weigh Herbaperine B and Polyvinylpyrrolidone (PVP k30) at a ratio of 1:6, add an appropriate amount of absolute ethanol to dissolve the drug and carrier, heat in a water bath at 60°C, and evaporate the solvent to dryness , rapidly cooled and solidified at -20°C, placed in a vacuum oven overnight, dried for 8 hours, pulverized, and passed through a 80-mesh sieve to obtain a solid dispersion of boronin B.

[0029] According to the calculation of preparing 1000 tablets, take by weighing 21g of the boronin B solid dispersion, 60g of pregelatinized starch, and 180g of lactose, and mix evenly; use 10% starch slurry as a wetting agent to make a soft material, granulate with a 20-mesh sieve, wet The pellets were dried at 60°C. Use a 24-mesh sieve to sieve the granules, add 6g of silicon dioxide, mix well, and press into tablets. (Each tablet contains 3mg of herbacetin B)

[0030] The appearance, loading difference, friability and...

Embodiment 2

[0033] The preparation of the boronine B solid dispersion is the same as in Example 1.

[0034] According to the calculation of preparing 1000 tablets, take by weighing 21g of the boronin B solid dispersion, 60g of pregelatinized starch, and 180g of lactose, and mix evenly; use 10% starch slurry as a wetting agent to make a soft material, granulate with a 20-mesh sieve, wet The pellets were dried at 60°C. Use a 24-mesh sieve to sieve the granules, add 6g of silicon dioxide, mix well, put it into a capsule shell, and obtain the product. (Each capsule contains 3mg of Herbaberonine B)

[0035] The appearance, filling volume difference and dissolution rate of the prepared Herbaperine B capsules were in compliance with the relevant provisions of the 2010 edition of "Chinese Pharmacopoeia" Appendix IE Capsules and Appendix XA Dissolution Test Method. Specifically: clean appearance, no adhesion, deformation, leakage or rupture of the capsule shell, and no odor; the weight differenc...

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Abstract

The invention provides a pepromia pellucida B solid dispersoid, which is composed of pepromia pellucida B and a water-soluble carrier material according to weight ratio of 1:4-1:8. The pepromia pellucida B composition used for inhibiting angiogenesis comprises the following components by weight: 6-9 parts of pepromia pellucida B solid dispersoid, 20-30 parts of starch, 60-90 parts of lactose and 2-5 parts of silicon dioxide or magnesium stearate. The invention also provides a preparation method of the pepromia pellucida B solid dispersoid and the pepromia pellucida B composition.

Description

technical field [0001] The present invention relates to a composition of orthoperine B for inhibiting angiogenesis and a preparation method thereof. Background technique [0002] In contemporary times, malignant tumors have become the main diseases that cause human death, and their treatment costs are quite expensive. [0003] Tumor growth requires blood vessels to provide rich blood supply and nutrition. Therefore, only a large number of new blood vessels grow into the tumor parenchyma can ensure the continuous growth and metastasis of the tumor. At the same time, because the walls of new blood vessels are thin, tumor cells are easy to penetrate. Thus entering the blood circulation for transfer. Therefore, if the formation of new blood vessels can be inhibited, the blood supply of the tumor can be blocked to achieve the purpose of inhibiting the growth and metastasis of tumor cells. [0004] Tumor growth, metastasis, recurrence and prognosis are closely related to angioge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/365A61K47/32A61K47/34A61P35/00
Inventor 杨国红李桂秀杨义芳林梦感秦雪梅吴春珍
Owner SHANGHAI INST OF PHARMA IND CO LTD
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