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A method for preparing carbon nanotube composite conductive hydrogel coating modified electrode

一种碳纳米管复合、导电水凝胶的技术，应用在生物医用材料及医疗器械领域，能够解决电极失效、相容性差等问题，达到检测极限低、稳定性优异、良好生物相容性的效果

Inactive Publication Date: 2016-01-20
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to propose a method for preparing carbon nanotube composite conductive hydrogel coating on the metal electrode surface, the coating prepared by the method has excellent It has excellent electrochemical catalytic activity and good biocompatibility, which overcomes the shortcomings of traditional metal electrodes / biological interface, such as poor compatibility, easy inflammation and electrode failure, and can be used on the electrode surface of bioelectrochemical sensors to improve the sensor's performance. sensitivity

Method used

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  • A method for preparing carbon nanotube composite conductive hydrogel coating modified electrode
  • A method for preparing carbon nanotube composite conductive hydrogel coating modified electrode

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Step 1, preparation of carbon nanotube dispersion liquid.

[0040] Take 500mg multi-walled carbon nanotubes and put them into 200mL30% H 2 o 2 The solution was sonicated for 30 min, and then condensed and refluxed at 60° C. for 1 hour. The resulting solution was vacuum filtered through a 0.2 μm polyvinylidene fluoride membrane. Wash the filtered carbon nanotubes with deionized water until neutral, and then put them into a vacuum drying oven for drying. Add the dried carbon tube into 40mL mixed acid solution containing concentrated sulfuric acid and concentrated nitric acid (vH 2 SO 4 :vHNO 3 =3:1) were subjected to magnetic stirring for 1 hour, and then ultrasonically dispersed at 60 °C for 4 hours. The resulting dispersion is centrifuged to remove excess acid, and the centrifuged carbon nanotubes are washed with a large amount of deionized water until neutral. Finally, vacuum-dry at 80°C to obtain the required acidified carbon tubes.

[0041] Take 20 mg of acid...

Embodiment 2

[0051] Step 1, preparation of carbon nanotube dispersion liquid.

[0052] Weigh 40 mg of anionic surfactant sodium dodecylbenzene sulfonate and dissolve it in 30 mL of deionized water, and make it fully dissolved by magnetic stirring. After the dissolution is complete, 30 mg of carbon nanotube solid powder is slowly added while continuing magnetic stirring, so that the carbon nanotubes are fully dispersed in the surfactant solution. After magnetic stirring for 40 minutes, ultrasonic dispersion was used for 3 hours to obtain a uniform and stable carbon nanotube dispersion.

[0053] Step 2, preparation of carbon nanotube / hyaluronic acid composite sol.

[0054] Accurately weigh 3g of hyaluronic acid, add 100g of deionized water and stir with a magnetic stirrer, fully dissolve the solute hyaluronic acid at 80°C, and obtain a hyaluronic acid sol with a concentration of 3%; continue magnetic stirring, and carbon The nanotube dispersion liquid was slowly added dropwise to the hyalu...

Embodiment 3

[0061] Step 1, preparation of carbon nanotube dispersion liquid.

[0062] The carbon nanotubes were dispersed with the cationic surfactant cetyltrimethylammonium bromide. Weigh 40mg of cetyltrimethylammonium bromide and dissolve it in 40mL of deionized water, and make it fully dissolved by magnetic stirring. After the dissolution is complete, continue magnetic stirring while slowly adding 20 mg of carbon nanotube solid powder to fully disperse the carbon nanotubes in the surfactant solution. After magnetic stirring for 30 minutes, ultrasonic dispersion was used for 3 hours to obtain a uniform and stable carbon nanotube dispersion.

[0063] Step 2, preparation of carbon nanotube / sodium alginate composite sol.

[0064] Accurately weigh 2g of sodium alginate, add 100g of deionized water and stir with a magnetic stirrer, fully dissolve the solute sodium alginate at 80°C, and obtain a sodium alginate sol with a concentration of 2%; continue magnetic stirring, and carbon The nano...

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Abstract

The invention relates to the related fields of biomedical materials and medical devices, in particular to a method for preparing a carbon nanotube composite conductive hydrogel coating modified electrode by using an electrophoretic deposition method. Including steps: Step 1, preparing carbon nanotube dispersion; Step 2, preparing carbon nanotube composite polymer sol; Step 3, pretreatment of metal electrodes; Step 4, preparing composite conductive hydrogel coating by electrophoretic deposition; Fifth, the composite coating is cross-linked; the carbon nanotube composite conductive hydrogel coating is finally formed to modify the electrode, and the prepared electrode is placed in a phosphate buffer solution for later use. The present invention adopts a variety of methods for surface treatment of carbon nanotubes, and a variety of sol-gel phase transition or cross-linking methods, which overcomes the difficulty of dispersing carbon nanotubes and their composite materials in an aqueous solution system, easy agglomeration, potential biological security risks, etc.

Description

Technical field [0001] The present invention involves the areas of biomedical materials and medical device -related areas, and specially involves the method of using electrophoretic sedimentation legal carbon nanopardium composite conductive water gel coating to modify electrodes. Background technique [0002] The essence of the life process is the transfer of charge, and the process of this process needs to be achieved through a certain interface. The chemical electrode can be regarded as a more ideal platform for the graduate film structure and function, biomolecular or biomolecular charge transmission behavior.In recent years, the research and application of the built -in biosensor electrodes and nerve repair electrodes have attracted great attention, and they are widely used in real -time detection and clinical monitoring of specific biomolecules in the body.Long -term implantation and electrical signals in the electrode are transmitted between tissue and materials.However, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30
Inventor 郑裕东李伟林清华付晓利王鹏飞
Owner UNIV OF SCI & TECH BEIJING
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